Description
Rimantadine Kids Pharmacodynamics
Rimantadine is an antiviral agent, an adamantane derivative; it is active against various strains of influenza A virus. Being a weak base, rimantadine acts by increasing the pH of the endosomes, the membrane vacuoles that surround the viral particles after they enter the cell. Preventing acidification in these vacuoles blocks the fusion of the viral envelope with the endosome membrane, thus preventing the transfer of viral genetic material into the cell cytoplasm. Rimantadine also inhibits the exit of viral particles from the cell, i.e. it interrupts the transcription of the viral genome.
Indications
Prevention and early treatment of influenza A in children over 1 year of age.
Rimantadine prophylaxis may be effective in contacts with influenza patients at home, in the spread of infection in closed groups and at high risk of the disease during influenza epidemics.
Contraindications
– Severe renal insufficiency;
– Severe renal insufficiency;
– thyrotoxicosis;
– Pregnancy and breast-feeding;
– children under 1 year of age;
– hypersensitivity to rimantadine and drug components;
– Sucrose/isomaltase deficiency;
– glucose-galactose malabsorption;
– fructose intolerance.
Caution
Epilepsy (including anamnesis), moderate to mild renal/liver failure, diabetes, arterial hypertension, cerebral vascular arteriosclerosis, gastrointestinal diseases.
Because of the presence of sorbitol in the composition should be used with caution when vomiting, pain and discomfort in the stomach, diarrhea.
Administration during pregnancy and breast-feeding.
The use of the drug is contraindicated in pregnancy. If it is necessary to apply during lactation, breastfeeding should be discontinued.
Dosage and administration
- Is taken orally (after a meal), with water, in accordance with the instructions to the scheme (Medicinal or Prophylactic).
- For dosing, the package includes a measuring spoon of 2.5 ml and 5.0 ml.
- 5 ml of syrup contains 10 mg of the active substance.
- Therapeutic regimen:
- It is taken orally (after meals), with water, according to the following scheme: children from 1 to 3 years – on the first day 10 ml (2 teaspoons) of syrup (20 mg) 3 times a day (daily dose – 60 mg); 2 and 3 days – 10 ml 2 times a day (daily dose – 40 mg), 4 day – 5 day – 10 ml 1 time a day (daily dose – 20 mg).
- Children from 3 to 7 years of age – on the first day – 15 ml (3 tea spoons) of the syrup (30 mg) 3 times a day (daily dose – 90 mg); days 2 and 3 – 3 tea spoons 2 times a day (daily dose – 60 mg), day 4 – day 5 – 3 tea spoons once a day (daily dose – 30 mg).
- Children 7 to 10 years old take 25 ml (5 teaspoons) of syrup (50 mg) 2 times a day for 5 days (daily dose – 100 mg).
- Children 11 to 14 years old take 25 ml (5 teaspoons) of syrup (50 mg) 3 times a day for 5 days (daily dose – 150 mg).
- Prophylactic scheme:
- For prophylaxis use:
- children from 1 to 3 years – 10 ml (2 teaspoons) of syrup (20 mg) once a day, children from 3 to 7 years – 15 ml (3 teaspoons) of syrup (30 mg) once a day, children over 7 years – 25 ml (5 teaspoons) of syrup (50 mg) once a day for 10-15 days.
- Attention! The daily dose of rimantadine should not exceed 5 mg per kg body weight.
