Description
Mycoderil Pharmacodynamics
Mycoderil®, spray for external use, 1% is an antifungal agent intended for external use, belonging to the class of allilamines. Its active ingredient is naphthifine. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. Naftifine, affecting squalene epoxidase, does not affect the cytochrome P-450 system.
Naphtifine is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, yeast and yeast-like fungi (Candida spp., Pityrosporum), mold fungi (Aspergillus) and other fungi (e.g. Sporothrix schenckii). Against dermatophytes and aspergillus naphthifin acts fungicidal. Against yeast fungi the drug has fungicidal or fungistatic activity depending on the strain of the microorganism. Naftifin has antibacterial activity against Gram-positive and Gram-negative microorganisms causing secondary bacterial infections.
Naphtifine has anti-inflammatory activity, which contributes to the rapid disappearance of inflammatory symptoms, especially itching.
Indications
– Fungal infections of smooth skin and skin folds;
– Interfinger mycoses;
– Fungal nail infections;
– skin candidiasis;
– pityriasis;
– Dermatomycoses (with or without itching).
Contraindications
Hypersensitivity to naphthyphine or propylene glycol; pregnancy and lactation period (safety and efficacy of the drug in this category of patients has not been studied).
Application of the drug to the wound surface is contraindicated.
Caution
Childhood (experience of clinical use is limited).
Administration during pregnancy and lactation
It is contraindicated in case of pregnancy and during breast-feeding (safety and efficacy in this group of patients has not been investigated).
has not been studied).
Dosage and administration method.
- Outwardly.
- In dermatomycosis and candidiasis of the skin.
- Micoderil®, spray for external use, 1% is applied once a day to the affected skin surface and its neighbors after thorough cleaning and drying, leaving approximately 1 cm of healthy skin at the edge of affected area. Duration of treatment: in dermatomycosis – 2-4 weeks (if necessary – up to 8 weeks), with candidiasis – 4 weeks.
- With lesions of the nails (onychomycosis).
- Before the first use of the drug, remove the affected part of the nail with scissors and a nail file as much as possible. The drug is used 2 times a day, the duration of treatment for onychomycosis is up to 6 months. To prevent recurrence of the infection, you should continue using the drug for at least 2 weeks after the disappearance of clinical symptoms.
- If after treatment, no improvement occurs or symptoms worsen, or new symptoms appear, consult a doctor. Use the drug only according to the indications, the route of administration and the doses stated in the instructions for use.
