Description
Levomycetin Pharmacodynamics
Bacteriostatic broad spectrum antibiotic, disrupts protein synthesis in a microbial cell (having liposolubility, penetrates through the cell membrane of bacteria and reversibly binds with 50S subunit of bacterial ribosomes, where amino acid transfer to growing peptide chains is delayed, which leads to disruption of protein synthesis). Effective against strains of bacteria resistant to penicillin, tetracyclines, sulfonamides. Active against Neisseria gonorrhoeae, Chlamydia trachomatis, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, some Enterobacter and Neisseria species, Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus haemolyticus), Moraxella lacunata, rickettsia and mycoplasmas.
Not effective against acid-resistant bacteria, anaerobes, Acinetobacter spp. and Serratia marcescens.
Indications
Bacterial eye infections caused by susceptible microflora: conjunctivitis, keratitis, blepharitis, blepharoconjunctivitis, keratoconjunctivitis, neuroparalytic keratitis in the presence of secondary bacterial infection.
Contraindications
Levomycetin is contraindicated in hypersensitivity to chloramphenicol and other components of the drug, suppression of medullary hematopoiesis, acute intermittent porphyria, glucose-6-phosphate dehydrogenase deficiency, renal and/or liver failure, pregnancy, breast-feeding, during infancy (up to 4 weeks).
Caution
Skin diseases (psoriasis, eczema, fungal lesions), early childhood, in patients who received previous treatment with cytostatic drugs or radiation therapy.
Administration during pregnancy and lactation
The drug is contraindicated during pregnancy and during breast-feeding.
Dosage and administration
- Topically. Dosage: Adults and children: 1 drop 3-4 times a day into conjunctival sac.
- Recommended course of treatment 7-10 days. Extension of treatment course is possible only by doctor’s prescription. Use the drug only according to the method of administration and in those doses that are specified in the instructions. If necessary, please consult a doctor before using the drug.
