Description
Triacorte Pharmacodynamics
Fluorinated glucocorticosteroid drug, has a pronounced anti-inflammatory, anti-allergic and anti-exudative effect.
Interacting with a specific protein receptor in the target tissues, it regulates -expressing corticoid-dependent genes and thus affects protein synthesis. Reduces the formation, release and activity of inflammatory mediators (histamine, kinin, prostaglandins, lysosomal enzymes). Suppresses cell migration to the site of inflammation; reduces vasodilation and increased vascular permeability in the inflammation focus. Stabilizes lysosomal membrane enzymes of leukocytes; inhibits antibody synthesis and disrupts antigen recognition. Inhibits the release of interleukin 1, interleukin 2, gamma interferon from lymphocytes and macrophages. Induces the formation of lipocortin, inhibits the release of inflammatory mediators by eosinophils and stabilizes mast cell membranes. All these effects are involved in suppressing the inflammatory response in tissues in response to mechanical, chemical or immune damage.
Indications
Simple and allergic dermatitis, eczema, atopic dermatitis, diffuse neurodermitis, psoriasis, annular granuloma, ruber lichen planus, simple chronic lichen (limited neurodermitis), toxidermia, keloid scars, alopecia nervosa, full alopecia, insect bites.
Contraindications
Hypersensitivity to triamcinolone and other ingredients of the drug, bacterial, viral and fungal skin diseases, pregnancy, lactation.
Directions for use and dosages
- The ointment is applied evenly, thinly to the affected skin areas 1-3 times a day. You can use with the occlusive dressing for lichenified manifestations.
- Duration of treatment depends on the nature of the disease and effectiveness of therapy, usually making 5-10 days. If the disease persists, the course of treatment may be prolonged up to 25 days. It is not recommended to use more than 4 weeks.
