Description
Octolipen Pharmacodynamics
Thioctic acid (α-lipoic acid) is found in the human body, where it acts as a coenzyme in the oxidative phosphorylation reactions of pyruvic acid and alpha-keto acids. Thioctic acid is an endogenous antioxidant. Thioctic acid helps to protect the cell from the toxic effects of free radicals arising from metabolic processes, neutralizes exogenous toxic compounds. Thioctic acid increases the concentration of endogenous antioxidant glutathione, which reduces the severity of symptoms of polyneuropathy. The drug has hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effect; it improves the trophism of neurons. Synergistic action of thioctic acid and insulin results in increased glucose utilization.
Indications
Diabetic and alcoholic polyneuropathy.
Contraindications .
– Hypersensitivity to thioctic acid or other components of the drug.
– Pregnancy and breast-feeding (there is insufficient experience in using the drug).
– Childhood under 18 years of age (effectiveness and safety of use have not been determined).
Dosage and administration method
- The drug is taken orally, on an empty stomach, 30 minutes before breakfast, without chewing, with water.
- The recommended dose is 600 mg (2 capsules) 1 time a day.
- In isolated (severe) cases, treatment begins with the appointment of parenteral form of Octolipen® (solution for infusion) during 2-4 weeks and then is transferred to oral treatment with Octolipen® (sequential therapy).
- The type and duration of treatment is determined by the physician.
