Description
Retinol Palmitate Pharmacodynamics
Vitamin A has a restorative effect, normalizes tissue metabolism, is involved in redox processes (due to the large number of unsaturated bonds), the synthesis of mucopolysaccharides, proteins, lipids, mineral metabolism, cholesterol formation processes. Increases the production of lipase and trypsin, enhances myelopoiesis and cell division processes. Has a positive effect on the function of the lacrimal, sebaceous and sweat glands, increases resistance to diseases of the mucous membranes, respiratory tract and intestines; increases the body’s resistance to infection. It enhances division of epithelial skin cells, rejuvenates cell population, inhibits keratinization processes, increases synthesis of glycosaminoglycans, activates interaction of immunocompetent cells among themselves and epidermal cells. Stimulates cell regeneration. Participates in the processes of photoreception (promotes human adaptation to darkness). Local action is due to the presence of specific retinol-binding receptors on the surface of epithelial cells.
Indications
Hypovitaminosis, avitaminosis A. In the complex therapy:
– Infectious-inflammatory diseases (measles, dysentery, flu, tracheitis, bronchitis, etc.),
– Lesions and skin diseases (cracks, ichthyosiform erythrodermia, acne, hyperkeratosis, seborrheic dermatitis, psoriasis, neurodermatitis, some forms of eczema, tuberculosis of the skin),
– eye diseases (retinitis pigmentosa, hemeralopia, xerophthalmia, keratomalacia, eczematous eyelid lesions),
– Gastrointestinal diseases (erosive gastroduodenitis, gastric and duodenal ulcers),
– liver cirrhosis.
Appointed for the prevention of formation of concrements in the biliary and urinary tract.
Contraindications .
Hypersensitivity to the components of the drug, hypervitaminosis A, pregnancy, cholelithiasis, chronic pancreatitis, acute inflammatory skin diseases.
With caution:
Use in nephritis, heart failure II-III degree, alcoholism, viral hepatitis, renal failure, old age, childhood.
Pregnancy and lactation:
It is not recommended to take the drug during pregnancy and lactation.
Directions for use and dosage
- The drug should be used under the supervision of a physician. The drug is taken orally after a meal, early in the morning or late in the evening.
- Therapeutic doses for adults in case of light and moderate avitaminosis are up to 33000 IU/day, for children – 1000-5000 IU/day depending on age.
- In cases of eye disease, adults are prescribed 50000-100000 IU/day and 0.02 g of riboflavin at the same time.
- In dermatology in treatment of acne and ichthyosiform erythrodermia in adults – 100000-300000 IU/day, in children 5000-10000 IU/kg/day.
- In case of skin diseases retinol palmitate is prescribed for adults 50000-100000 IU/day.
- In gastroenterology it is prescribed for 50000 ME per day.
- Single doses of retinol palmitate should not exceed 50000 ME for adults and 5000 ME for children. Daily doses for adults are 100,000 ME for adults and 20,000 ME for children. For the treatment of acne and ichthyosiform erythroderma in adults 100000-300000 ME.
