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Pyridoxine, benfotiamine (Combilipen Neuro Tabs) 100 mg + 100 mg – [60 tablets]


Complex of vitamins of group b

SKU: 61773 Category:


Combilipen neuro Pharmacodynamics
Benfotiamine, a fat-soluble derivative of thiamine (vitamin B1), is phosphorylated in the body to the biologically active coenzymes thiamine diphosphate and thiamine triphosphate. Thiamine diphosphate is a coenzyme of pyruvate decarboxylase, 2-oxyglutarate dehydrogenase and transketolase, thus participating in the pentose phosphate cycle of glucose oxidation (aldehyde group transfer).
The phosphorylated form of pyridoxine (vitamin B6), pyridoxalphosphate, is a coenzyme of several enzymes that influence all stages of non-oxidative amino acid metabolism. Pyridoxal phosphate is involved in the decarboxylation of amino acids and therefore in the formation of physiologically active amines (e.g., address-naline, serotonin, dopamine, tyramine). Pyridoxal phosphate is also involved in anabolic and catabolic processes, e.g. as a coenzyme of such transaminases as glutamate oxalocetate transaminase, glutamate pyruvate transaminase, gamma-aminobutyric acid (GABA) and a-ketoglutarate transaminase, and in various amino acid degradation and synthesis reactions.
Vitamin B6 is involved in 4 different steps of tryptophan metabolism.

Neurological diseases with confirmed vitamin B1 and B6 deficiency.

Contraindications .
– Hypersensitivity to thiamine, benfothiamine, pyridoxine and / or any excipient in the preparation;
– Pregnancy, breast-feeding;
– Under 18 years of age (due to lack of clinical data).
If you have any of the above mentioned diseases/conditions or risk factors, consult your physician before using this medicine.
Administration during pregnancy and breastfeeding
The use of the drug Kombilipen® Neuro Tabs is contraindicated in pregnancy (see section “Contraindications”).
Breastfeeding period
Kombilipen® Neuro Tabs is contraindicated during breastfeeding (see section “Contraindications”).
Before application of Kombilipen® Neuro tabs if you are pregnant or if you suspect that you may be pregnant or plan to become pregnant, consult your physician.

Dosage and administration

  • Oral.
  • The tablet should be swallowed with plenty of liquid.
  • If not prescribed by the doctor, an adult patient should take 1 tablet per day.
  • In acute cases, after consulting the doctor, the dose may be increased to 1 tablet 3 times a day. After four weeks of treatment the physician will decide whether a higher dose of vitamin B6 and B1 should be continued and whether the increased dose should be reduced to 1 tablet per day. If possible, the dose should be reduced to 1 tablet daily to reduce the risk of vitamin B6-associated neuropathy.
  • If there is no improvement after treatment, or if symptoms worsen or new symptoms develop, consult a physician. Use the drug only according to the indications, the route of administration and the dosage indicated in the instructions.