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Cyanocobalamin injections 500 mcg 1 ml – [10 ampoules]


Vitamin b12

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Cyanocobalamin Pharmacodynamics
Vitamin B12. In the body (mainly in the liver) it is converted into methylcobalamin and 5-deoxyadenosylcobalamin. Methylcobalamin is involved in the transformation of homocysteine into methionine and S-adenosylmethionine – the key metabolic reactions of pyrimidine and purine bases (and therefore DNA and RNA). If the vitamin is deficient in this reaction, it can be replaced by methyltetrahydrofolic acid, with impaired folic metabolic reactions. 5-deoxyadenosylcobalamin serves as a cofactor in the isomerization of L-methylmalonyl-CoA into succinyl-CoA, an important reaction in carbohydrate and lipid metabolism.
Vitamin B 12-deficiency leads to impaired proliferation, rapidly dividing cells of hematopoietic tissue and epithelium, as well as to impaired formation of myelin sheath of neurons.


Conditions involving vitamin B12 deficiency: B12-deficiency anemia, in the treatment of anemia (including iron deficiency, post-hemorrhagic, aplastic, anemia caused by toxic substances and / or drugs).
In complex therapy:
In neurology: neuralgia (including trigeminal neuralgia), polyneuropathy (including alcoholic).
With prophylactic purpose – when prescribing biguanides, PASK, ascorbic acid in high doses, gastric and intestinal pathology with impaired absorption of vitamin B12 (resection of the stomach, small intestine, Crohn’s disease, malabsorption syndrome, sprue), radiation sickness.


Contraindications .
Hypersensitivity to the components of the drug, thromboembolism, erythraemia, erythrocytosis, pregnancy (there are separate indications of the possible teratogenic effect of B-group vitamins in high doses), lactation.
Angina, benign and malignant tumors, accompanied by megaloblastic anemia and vitamin B12 deficiency, a tendency to blood clots.


Dosage and administration method
  • Cyanocobalamin is used subcutaneously, intramuscularly, intravenously.
  • Subcutaneously, in B12-deficiency anemia – 100-200 micrograms / day every other day; in B12-deficiency anemia with compounds of nervous system disorders – 400-500 micrograms / day in the first week – daily, then with intervals between injections up to 5-7 days (folic acid is prescribed simultaneously); during remission, the maintenance dose – 100 micrograms / day 2 times a month, if there are neurological symptoms – 200-400 micrograms 2-4 times a month.
  • In acute post-hemorrhagic and iron deficiency anemia – 30-100 micrograms 2-3 times a week; in aplastic anemia, anemia caused by toxic substances and/or drugs – 100 micrograms until clinical and hematological improvement. In disorders of the nervous system – 200-400 micrograms 2-4 times a month.
  • In neurology: neuralgia (including trigeminal neuralgia), polyneuropathy (including alcohol) – 200-500 micrograms a day for 2 weeks.
  • For prophylactic purposes – 60-100 micrograms daily for 20-30 days.
  • To eliminate vitamin B12 deficiency, administer intramuscularly (v/m) or intravenously (v/v) 1 mg daily for 1-2 weeks.
  • Infants with alimentary anemia and prematurely born children injected subcutaneously 30 micrograms daily for 15 days.