Paracetamol, ascorbic acid (Paracetamol Extratab) 500 mg + 150 mg – [20 tablets]

Paracetamol has analgesic and antipyretic effects. The drug blocks cyclooxygenase 1 and 2 mainly in the central nervous system (CNS), affecting the centers of pain and thermoregulation. In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on cyclooxygenase, which explains its almost complete lack of anti-inflammatory effect. The drug has no adverse effect on water-salt metabolism (sodium and water retention) and gastrointestinal (GI) mucosa, due to its lack of effect on prostaglandin synthesis in peripheral tissues. The possibility of methemoglobin formation is unlikely.

Ascorbic acid (vitamin C) is not formed in the human body, comes only with food.

Physiological functions: is a cofactor of some hydroxylation and amidation reactions – transfers electrons to enzymes, providing them with a reducing equivalent. It participates in reactions of hydroxylation of proline and lysine residues of procollagen to form hydroxyproline and hydroxylysine (poststratal modification of collagen), oxidation of lysine side chains in proteins to form hydroxytrimethyllysine (in the synthesis of cartinite), oxidation of folic acid to folic acid, metabolism of drugs in liver microsomes and hydroxylation of dopamine to form noradrenaline.

Increases the activity of amidifying enzymes involved in the processing of oxytocin, antidiuretic hormone and cholestycystokinin. Participates in steroidogenesis in the adrenal glands.

The main role at the tissue level is participation in the synthesis of collagen, proteoglycans and other organic components of intercellular substance of teeth, bones and capillary endothelium.

Paracetamol EXTRATAB is used as:

-antipyretic agent for infectious and inflammatory diseases (SARS, including influenza);

Pain reliever for mild to moderately expressed pain syndrome (headache, toothache) of non-inflammatory origin, neuralgia, muscle and joint pain, algodysmenorrhea.

Contraindications .

Severe renal and hepatic diseases, including renal and/or hepatic insufficiency, glucose-6-phosphate dehydrogenase deficiency; gastrointestinal erosive-ulcerative lesions (acute phase), gastrointestinal bleeding; children under 6 years of age; pregnancy

(I-III trimesters), lactation.

Caution: erosive-ulcerative lesions of the gastrointestinal tract (history), congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes).

Blood diseases (thrombocytopenia, leukopenia, agranulocytosis), sideroblast anemia, thalassemia.

Hemochromatosis, hyperoxaluria, urolithiasis.

Bronchial asthma. Alcoholism.