Description
Acecardol Pharmacodynamics
Non-steroidal anti-inflammatory drug (NSAID). The mechanism of action of acetylsalicylic acid is based on irreversible inhibition of COX, resulting in blockade of thromboxane A2 synthesis and suppression of platelet aggregation. It is believed that acetylsalicylic acid has other mechanisms of inhibiting platelet aggregation, which expands the field of its application in various vascular diseases. Acetylsalicylic acid also has anti-inflammatory, analgesic, antipyretic effects.
Indications
– Prevention of acute myocardial infarction in the presence of risk factors (e.g., diabetes mellitus, hyperlipidemia, arterial hypertension, obesity, smoking, old age);
– Prevention of recurrent myocardial infarction;
– unstable angina pectoris;
– Prevention of stroke (including in patients with transient cerebral haemorrhage);
– Prevention of transient impairment of cerebral circulation;
– Prevention of thromboembolism after surgeries and invasive vascular interventions (e.g., coronary artery bypass surgery, carotid endarterectomy, arterio-venous bypass surgery, carotid angioplasty)
– Prophylaxis of deep vein thrombosis and thromboembolism of the pulmonary artery and its branches (e.g., in case of prolonged immobilization due to a large surgical intervention).
Contraindications
– Gastrointestinal erosive-ulcerative lesions;
– gastrointestinal bleeding;
– hemorrhagic diathesis;
– Bronchial asthma, induced by taking salicylates and NSAIDs, Fernand-Vidal triad, (combination of bronchial asthma, recurrent polyposis of the nose and sinuses and ASA intolerance);
– Combined use with methotrexate at a dose of 15 mg/week or more;
– I and III trimesters of pregnancy;
– Lactation period (breast-feeding);
– under 18 years of age;
– Hypersensitivity to acetylsalicylic acid and/or other drug components;
– Hypersensitivity to other NSAIDs.
The preparation should be used with caution in case of gout, hyperuricaemia, with a history of gastrointestinal ulcers or bleeding, renal and hepatic insufficiency, bronchial asthma, chronic respiratory diseases, hay fever, nasal polyposis, allergic reactions to other drugs, in II trimester of pregnancy.
Dosage and administration
- Tablets should be taken orally, before meals, drinking plenty of fluids. The drug is intended for long-term use. The duration of therapy is determined by the attending physician.
- Prophylaxis in case of suspected acute myocardial infarction: 100-200 mg/ or 300 mg every other day (the first tablet should be chewed for faster absorption).
Prevention of first-time acute myocardial infarction in the presence of risk factors: 100 mg/ or 300 mg every other day. - Prevention of recurrent myocardial infarction, unstable angina pectoris, prevention of stroke and transient impairment of cerebral circulation, prevention of thromboembolic complications after surgical operations or invasive studies: 100-300 mg/
- Prevention of deep vein thrombosis and thromboembolism of the pulmonary artery and its branches: 100-200 mg/ or 300 mg/day.
