Description
Oxyfrine Pharmacodynamics
Oxymetazoline belongs to the group of alpha-adrenergic stimulants for local use. It has a vasoconstrictor effect. When administered intranasally it reduces swelling of the mucous membrane of the upper airways and nasal secretions. Restores nasal breathing.
Elimination of nasal cavity mucous membrane edema helps restore aeration of paranasal sinuses, middle ear cavity, which reduces the likelihood of bacterial complications (maxillary sinusitis, sinusitis, otitis media).
During local intranasal application and therapeutic concentrations it does not irritate and does not cause nasal mucosal hyperemia.
Oxymetazoline begins to act quickly, within minutes. Its duration of action is up to 12 hours.
Indications
– Treatment of acute respiratory diseases accompanied by a runny nose;
– allergic rhinitis;
– vasomotor rhinitis;
– Restoration of drainage in inflammation of paranasal sinuses, eustachitis, otitis media;
– To eliminate swelling before diagnostic manipulations in the nasal passages.
Contraindications .
– Hypersensitivity to the drug;
– Atrophic (dry) rhinitis;
– closed-angle glaucoma;
– condition after transsphenoidal hypophysectomy, surgical interventions on the dura mater (in anamnesis).
Caution:
In patients with diseases of the cardiovascular system (arterial hypertension, coronary heart disease, chronic heart failure, marked atherosclerosis, tachycardia, arrhythmias), carbohydrate metabolism disorders (diabetes), thyroid function disorders (hyperthyroidism), pheochromocytoma, chronic renal insufficiency, prostatic hyperplasia with clinical symptoms (urinary retention), increased intraocular pressure, porphyria, and in patients taking monoamine oxidase inhibitors during the previous 2 weeks and within 2 weeks after their withdrawal, tricyclic antidepressants, bromocriptine.
Pregnancy and lactation:
When used during pregnancy or breastfeeding, the recommended dose should not be exceeded. The drug may be used only in cases when the potential benefit to the mother exceeds the potential risk to the fetus and child.
Directions for use and dosages
- Intranasal.
- Oxyfrine, nasal drops 0.01% is indicated for use in children under 1 year of age.
- Children under 4 weeks of age are prescribed 1 drop of the drug in each nostril 2 to 3 times a day. From the 5th week of life to 1 year of age – 1-2 drops in each nostril 2-3 times a day.
- 1 drop of the drug contains 2.8 mcg oxymetazoline hydrochloride.
- The drug should be dropped in with the child’s head tilted back.
- The following procedure has also been proven effective: Depending on the age, 1-2 drops of the drug are put on absorbent cotton and rubbed into each nasal passage.
- If symptoms intensify or improvement does not come within 3 days, you should consult a doctor. Use in the recommended dose without consulting a doctor for no more than 7 days.
- If the drug is used frequently and for a long time, the feeling of “stuffy” nose may reappear or worsen. If these symptoms occur, discontinue treatment and consult a physician.
