Description
Latran Pharmacodynamics
Effectively prevents and eliminates nausea and vomiting, arising against the background of antitumor chemotherapy or radiation therapy, as well as in the postoperative period. The mechanism of action is due to the ability of ondansetron to selectively block serotonin 5-HT3 receptors. It is believed that stimulation of afferent fibers of the vagus nerve by serotonin released from enterochromaffin cells of the gastrointestinal mucosa plays an important role in the occurrence of nausea and vomiting during antitumor therapy. By blocking 5-HT3 receptors, ondansetron prevents the occurrence of the gag reflex. In addition, ondansetron inhibits central parts of the gag reflex by blocking 5-HT3-receptors of the floor of the IV ventricle (area postrema).
Indications
Prevention of nausea and vomiting during antitumor chemotherapy or radiation therapy; prevention and treatment of nausea and vomiting in the postoperative period.
Contraindications
I trimester of pregnancy, hypersensitivity to ondansetron.
Dosage and administration method
- Individual, depending on the indications and the treatment regimen.
