Description
Algesir Pharmacodynamics
Naproxen preparations have analgesic, antipyretic and anti-inflammatory effects. The mechanism of action is associated with non-selective inhibition of cyclooxygenase-1 and -2 (COX-1, COX-2) activity.
Naproxen is well soluble, quickly absorbed from the gastrointestinal tract and provides rapid onset of analgesic effect.
Indications
Naproxen is used for symptomatic therapy (to reduce pain, inflammation and decrease elevated body temperature) and has no effect on the progression of the underlying disease.
Disease of the musculoskeletal system (rheumatic soft tissue lesions, osteoarthritis of peripheral joints and spine, including radicular syndrome, tendovaginitis, bursitis).
Pain syndrome of mild to moderate severity: neuralgia, ossalgia, myalgia, lumboishyalgia, post-traumatic pain syndrome (sprains and bruises), accompanied by inflammation, headache, migraine, algodysmenorrhea, toothache.
As part of the complex treatment of infectious and inflammatory diseases of the ear, throat, nose with a pronounced pain syndrome (pharyngitis, tonsillitis, otitis).
Feverish syndrome in “colds” and infectious diseases.
Contraindications .
Hypersensitivity to naproxen or naproxen sodium or to any substance included in the medicinal product.
Complete or incomplete combination of bronchial asthma, recurrent nasal or paranasal sinus polyposis and intolerance to acetylsalicylic acid and other nonsteroidal anti-inflammatory drugs (NSAIDs) (including history).
Period after coronary artery bypass grafting.
Erosive ulcerative changes of the mucosa of the stomach or duodenum, active gastrointestinal bleeding.
Inflammatory bowel disease (non-specific ulcerative colitis, Crohn’s disease) in the acute phase.
Hemophilia and other disorders of blood clotting and hemostasis.
Cerebrovascular bleeding or other bleeding disorders.
Decompensated heart failure.
Severe hepatic insufficiency or active liver disease.
Severe renal insufficiency (creatinine clearance (CK) less than 30 ml/min), advanced renal disease, confirmed hyperkalemia.
Pregnancy, breastfeeding.
Childhood under 15 years of age.
Caution
Coronary heart disease, cerebrovascular disease, congestive heart failure, dyslipidemia/hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, impaired renal function (CK 30-60 ml/min), history of gastrointestinal ulcers (GI), presence of Helicobacter pylori infection, use in elderly patients, systemic lupus erythematosus or mixed connective tissue diseases (Sharp’s syndrome), long-term use of PPV, frequent alcohol consumption, severe somatic diseases, concomitant therapy with the following drugs: anticoagulants (e.g., warfarin), antiaggregants (e.g., acetylsalicylic acid, clopidogrel), oral glucocorticoids (e.g., prednisolone), selective serotonin reuptake inhibitors (e.g., citalopram, fluoxetine, paroxetine, sertraline).
Use in pregnancy and during breastfeeding
Naproxen is not recommended for use during pregnancy and breastfeeding.
How to use and dosages.
- Inside. Tablets should be taken with a sufficient amount of water.
Recommended therapy regimen - Adults, children 15 years and older.
Usual daily dose used for pain relief is 2-3 tablets (550-825 mg). Maximum daily dose is 3 tablets (825 mg). The duration of use is not more than 5 days.
When using naproxen as an antipyretic agent, the initial dose is 2 tablets and then 1 tablet (275 mg) every 8 hours. - For prevention and treatment of migraine attacks the initial recommended dose is 2 tablets (550 mg), if necessary it can be taken 1 tablet (275 mg) every 8-12 hours. The maximum daily dose is 3 tablets (825 mg).
- To relieve menstrual pain and cramps, pain after IUD insertion and other gynecological pain, it is recommended to prescribe the drug in an initial dose of 2 tablets (550 mg), then 1 tablet (275 mg) every 8 hours.
- Children
Naproxen is contraindicated for use in children under 15 years of age.
Elderly patients (> 65 years) - Patients over 65 years of age should take the drug as required every 12 hours.
To reduce the risk of gastrointestinal adverse events, the drug should be taken in the lowest effective dose with the shortest possible course.
Inform your doctor or pharmacist if you get the impression that the effect of the drug is very strong or weak.
