Description
Paracetamol Pharmacodynamics
Non-narcotic analgesic, blocks COX1 and COX2 mainly in the CNS, affecting the centers of pain and thermoregulation. In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX, which explains the almost complete absence of anti-inflammatory effect. The absence of blocking effect on Pg synthesis in peripheral tissues explains its lack of negative effects on water-salt metabolism (Na+ and water retention) and gastrointestinal mucosa.
Indications
Used in children from 3 months to 12 years as:
– An antipyretic for acute respiratory illnesses, influenza, childhood infections, post-acute reactions and other conditions accompanied by elevated body temperature;
– Painkiller for pain syndrome of mild to moderate intensity, including: headache, toothache, muscle pain, neuralgia, pain from injuries and burns.
Contraindications
Hypersensitivity, period of infancy (up to 1 month).
With caution
Renal and hepatic failure, benign hyperbilirubinemia (including Gilbert syndrome), viral hepatitis, blood diseases (leukopenia, thrombocytopenia), early infant age (less than 3 months).
Dosage and administration
- Rectally.
- Frequency of intake of 2 – 4 times a day, an interval of at least 4 hours.
- The dose depends on the age and body weight of the child. The average single dose is 10-12 mg/kg body weight. The maximum daily dose of paracetamol should not exceed 60 mg/kg of body weight.
- Depending on age, the following single doses are recommended:
- 6 to 12 months – 0.5-1 suppositories (50-100 mg);
- 1 to 3 years of age – 1.5 to 1.5 suppositories (100 to 150 mg);
- 3 to 5 years – 1.5-2 suppositories (150-200 mg);
- 5 to 10 years – 2.5-3.5 suppositories (250-350 mg);
- 10 to 12 years old – 3.5-5 suppositories (350-500 mg).
- Do not take the drug for more than 3 days as antipyretic and 5 days as analgesic without prescription! In children under 3 months of age, it can be used for fever caused by vaccination (vaccination). For all other indications, Paracetamol in children under 3 months of age should only be used as prescribed by a doctor.
