Description
Meldonium Pharmacodynamics
Meldonium is a structural analogue of the carnitine precursor, gamma-butyrobetaine (GBB), a substance found in every cell of the human body.
Under conditions of increased stress, meldonium restores the balance between cellular oxygen supply and demand, eliminates the accumulation of toxic products of metabolism in cells, protecting them from damage, and has a tonic effect. Its use increases the body’s resistance to stress and its ability to quickly restore energy reserves.
The drug has a stimulating effect on the central nervous system (CNS), increasing motor activity and physical endurance. Thanks to these properties, Meldonium is used for increasing physical and mental performance.
Indications
Reduced performance, mental and physical overload.
Contraindications
Hypersensitivity to meldonium or any other component of the drug. Increased intracranial pressure (with venous outflow disorders, intracranial tumors), Pregnancy and breast-feeding.
Age under 18 years (safety has not been confirmed).
Caution
Dosages 250 mg, 500 mg.
In liver and/or kidney disease.
Administration during pregnancy and breastfeeding.
Dosages 250 mg, 500 mg
The safety of application in pregnant women has not been investigated; therefore, to avoid possible adverse effects on fetus, it is contraindicated for pregnant women. Excretion into the milk and the effect on the health of the baby have not been studied, so stop breast-feeding if necessary.
Before using Meldonium, if you are pregnant or think that you may be pregnant, or if you are planning to become pregnant, consult your physician.
Dosage and administration
- By mouth, before meals.
- Because of the possible development of excitatory effects, it is recommended to use in the morning and no later than 17.00 when taken several times a day.
- The maximum single and daily dose for adults is 500 mg (2 capsules). The entire dose is taken in the morning in one sitting or divided into two doses.
- The course of treatment is 10-14 days.
- If necessary, treatment should be repeated in 2-3 weeks.
- If after treatment no improvement, or symptoms worsen, or new symptoms appear, consult a doctor. Use the drug only according to those indications, that method of use and in those doses specified in the instructions.
