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Melatonin (Melarena) 0.3 mg – [30 tablets]


It has an adaptogenic, sedative, hypnotic effect.

SKU: 61989 Category:


Melarena Pharmacodynamics
A synthetic analogue of the pineal body hormone (epiphysis) melatonin, has an adaptogenic, sedative and hypnotic effect. Normalizes circadian rhythms. Increases the concentration of gamma-aminobutyric acid (FAMK) and serotonin in the midbrain and hypothalamus, changes the activity of pyridoxal kinase, involved in the synthesis of GABA, dopamine and serotonin. Regulates the sleep-wake cycle, daily changes in locomotor activity and body temperature, has a positive effect on the brain’s inellectual and mental functions, and on the emotional-personal sphere. Helps to organize the biological rhythm and normalize night sleep. Improves the quality of sleep. Accelerates falling asleep, reduces the number of night awakenings, improves feelings after morning awakening, does not cause a feeling of lethargy, frazzled and tiredness upon awakening. Makes dreams more vivid and emotionally rich.
Adapts the body to rapid change of time zones, reduces stress reactions, regulates neuroendocrine functions. Adapts the body of weather-sensitive people to changes in weather conditions. Exhibits immune stimulating and antioxidant properties. Inhibits the secretion of gonadotropins and, to a lesser extent, other adenohypophysis hormones (corticotropin, thyrotropic hormone, somatotropic hormone). It is not addictive or addictive.

0.3 mg tablets.
Prophylaxis and treatment course:
Desynchronosis (violation of the normal circadian rhythm) due to rapid movement between the Earth’s time zones, in violation of the light regime, including people engaged in shift work or shift work.
Fatigue, sleep disorders (including elderly patients).
Depressive syndrome.

Contraindications .
Hypersensitivity to melatonin and other drug components; autoimmune diseases, allergic diseases; lymphogranulematosis, leukemia, lymphoma, myeloma, epilepsy, diabetes, chronic renal failure; severe renal failure (for 3 mg dosage); hepatic failure; pregnancy, breast-feeding; age under 18 years (effectiveness and safety of use are not established).
Administration during pregnancy and breast-feeding
The drug is contraindicated for use during pregnancy and breast-feeding.

How to use and dosages.

  • Inside.
  • Tablets 0.3 mg.
    One tablet once a day for 30-40 minutes before bedtime. The duration of treatment is determined individually (from 6 to 8 weeks). It is possible to repeat courses.
  • Tablets 3 mg.
    In violation of sleep, desynchronosis – 1 tablet once a day for 30-40 minutes before going to sleep.
  • In application as adaptogen in change of time zones, 1 tablet 1 day before flight and during the next 2-5 days – 1 tablet 30-40 minutes before sleep.
  • The maximum daily dose is 6 mg.
  • Elderly patients
    Melatonin metabolism decreases with age, which should be considered when choosing a dosing regimen for elderly patients. Taking this into account, in elderly patients it is possible to take the drug 60-90 minutes before sleep.
  • Renal failure
    The effect of varying degrees of renal impairment on the pharmacokinetics of melatonin has not been studied, so melatonin should be used with caution in these patients. In patients with severe renal insufficiency, the use of the drug is not recommended.
  • Liver failure
    Melatonin has not been used in patients with hepatic impairment. Significantly elevated plasma concentrations of endogenous melatonin during the day have been observed in patients with hepatic impairment. In patients with hepatic impairment, use of the drug is not recommended.