Description
Loratadine Pharmacodynamics
Blocker of H1-histamine receptors (long-acting). Suppresses the release of histamine and leukotriene C4 from mast cells. Prevents the development and facilitates the course of allergic reactions. It has anti-allergic, antipruritic, antiexudative action. Reduces capillary permeability, prevents the development of tissue edema, relieves spasms of smooth muscles. Anti-allergic effect develops in 30 minutes, reaches its maximum in 8-12 hours and lasts for 24 hours. It does not affect the central nervous system and is not addictive (as it does not penetrate through the blood-brain barrier).
Indications
Allergic rhinitis (seasonal and year-round), conjunctivitis, pollinosis, urticaria (including chronic idiopathic), Quincke’s edema, pruritic dermatoses; pseudo-allergic reactions caused by histamine release; allergic reactions to insect bites.
Contraindications .
Hypersensitivity. Pregnancy, lactation, children under 3 years of age.
With caution:
Liver failure.
Dosage and administration:
- Inside.
- Adults and children over 12 years: 10 mg (1 tablet) once a day. Daily dose is 10 mg. Children from 3 to 12 years of age take 5 mg (1/2 tablet) once a day. The daily dose is 5 mg. For children with body weight over 30 kg – 10 mg of the drug once a day. Daily dose – 10 mg.
- Directions for use and dosages
- Orally in adults and children over 12 years of age and if body weight over 30 kg – 10 mg once a day.
- For children from 2 to 12 years of age with body weight less than 30 kg – 5 mg once a day.
