Description
Calmirex Pharmacodynamics
Tolperizone hydrochloride is a myorelaxant of the central mechanism of action. It has membrane stabilizing, local anesthetic effect, inhibits conduction of nerve impulses in primary afferent fibers and motor neurons, which leads to blocking of spinal mono- and polysynaptic reflexes. Probably mediates the blocking of mediator release by inhibition of calcium ions entry into synapses. Inhibits the conduction of excitation along the reticulospinal pathway in the brainstem. Regardless of the effect on the central nervous system (CNS), it increases peripheral blood flow. A weak antispasmodic and antiadrenergic effect of tolperizone may play a role in the development of this effect.
Lidocaine hydrochloride has local anesthetic effect and has no systemic action when dosed according to the instructions.
Indications
– Hypertonicity and spasm of the transverse striated muscles, arising due to organic diseases of the CNS (including lesions of the pyramidal pathways, multiple sclerosis, stroke, myelopathy, encephalomyelitis), the musculoskeletal system (including spondylosis, spondiloarthrosis, cervical and lumbar syndromes, arthrosis of large joints);
– Rehabilitation treatment after orthopedic and trauma surgeries.
As part of the complex therapy:
– Obliterating vascular diseases (obliterating atherosclerosis, diabetic angiopathy, obliterating thrombangiitis, Raynaud’s disease, diffuse scleroderma);
– diseases arising from disorders of vascular innervation (acrocyanosis, intermittent angioneurotic dysbasia).
Contraindications
– Hypersensitivity to the components of the drug, including lidocaine;
– Severe myasthenia gravis;
– Pregnancy and lactation;
– Childhood and adolescence under 18 years of age.
Caution:
The drug should be used with caution in renal and hepatic insufficiency. Dosage adjustment is not required.
Dosage and administration method
- Daily intramuscularly – 100 mg twice a day or intravenously – 100 mg once a day in adults.
