Description
Vartocid Pharmacodynamics
Imihimod – immunomodulatory agent for external use, is a modifier of the immune response, does not have direct antiviral activity. The action is due to the induction of interferon alpha, tumor necrosis factor and other cytokines. When the drug is used externally, a decrease in angiogenesis processes is observed due to increased production of interleukin-18 and interferon-gamma.
Indications
Treatment of external acute condylomas localized on the external genitalia and/or in the perianal area in adults.
Contraindications
Hypersensitivity to imihimod, auxiliary components of the drug. Pregnancy, breast-feeding, children under 18 years of age.
Administration during pregnancy and breast-feeding:
The drug is not prescribed for pregnant women and women during breast-feeding.
Dosage and administration.
- Outwardly. The drug is used preferably at night before going to bed and leave on the skin for 6-10 hours. The cream is applied only to the affected pre-cleaned skin with a thin layer and gently rub until completely absorbed. The treated area of the skin should not be covered with bandages. Do not use excessive amounts of cream. After the specified time, the cream should be washed off with warm water and soap with a neutral pH.
- A single (daily) dose of the drug is 10 mg of cream per 1 cm2 of skin surface (a cream strip 2 mm in diameter and 0.5 cm long). The maximum application area is 25 cm2, which corresponds to the maximum dose of the drug – 250 mg. The preparation is applied once a day, 3 times a week (e.g. Monday, Wednesday, Friday or Tuesday, Thursday and Saturday) until genital or perianal condylomas have completely disappeared, but not for more than 16 weeks.
- If you forget to apply the cream as scheduled, apply the missed dose as soon as possible and then restore the regular treatment schedule. Do not apply the cream more than once a day.
