Description
Next Pharmacodynamics.
Combined drug, has analgesic, anti-inflammatory and antipyretic effects.
Paracetamol is a non-narcotic analgesic, has antipyretic and analgesic effect, due to the blockade of cyclooxygenase in the central nervous system and effects on the pain and thermoregulation centers.
Ibuprofen is a non-steroidal anti-inflammatory drug, has analgesic, anti-inflammatory and antipyretic effect due to non-selective inhibition of cyclooxygenase activity, which regulates the synthesis of prostaglandins.
The drug components affect both central and peripheral mechanisms of pain syndrome formation. Directed, complementary action of the two components has a rapid therapeutic effect and a pronounced analgesic effect.
Indications
Headache (including migraine);
– toothache;
– Algodysmenorrhea (painful menstruation);
– neuralgia;
– myalgia;
– back pain;
– Joint pain, pain syndrome in inflammatory and degenerative diseases of the musculoskeletal system;
– Pain from contusions, sprains, dislocations, fractures;
– Post-traumatic and postoperative pain syndrome;
– Fevers (including influenza and colds).
The drug is used as a symptomatic therapy for fevers, headache, muscle pain in acute respiratory diseases and influenza. The drug is intended for symptomatic therapy, to reduce pain and inflammation at the time of use, it has no effect on the progression of the disease.
Contraindications
Hypersensitivity to the components of the drug, including other nonsteroidal anti-inflammatory drugs (NSAIDs);
– gastrointestinal erosive and ulcerative diseases (acute phase), gastrointestinal bleeding;
– progressive kidney disease;
– severe renal insufficiency (creatine clearance (CK) less than 30 ml/min);
– severe hepatic insufficiency or active liver disease;
– blood clotting disorders (hemophilia, prolonged bleeding time, susceptibility to bleeding, hemorrhagic diathesis);
– cerebrovascular or other bleeding;
– complete or incomplete combination of bronchial asthma, recurrent nasal and paranasal sinus polyposis and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs, including in anamnesis;
– Chronic heart failure (functional class III-IV according to NYHA classification);
– Condition after coronary artery bypass grafting;
– confirmed hyperkalemia;
– Glucose-6-phosphate dehydrogenase deficiency;
– Pregnancy (III trimester);
– Breast-feeding period;
– children under 18 years of age.
Dosage and administration.
- Inside, after a meal.
1 tablet 3 times a day. The maximum daily dose of 3 tablets. - Duration of treatment: not more than 3 days as an antipyretic and not more than 5 days as an analgesic.
- Continued treatment with the drug is possible only after consultation with a doctor.
