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Dexketoprofen (Flamadex) injections 25 mg/ml 2 ml – [5 ampoules]


Non-steroidal anti-inflammatory drugs (nsaids)

Dexketoprofen (Flamadex) is intended for symptomatic therapy, to reduce pain and inflammation, does not affect the progression of the disease.

SKU: 63142 Category:


Dexketoprofen (Flamadex) Pharmacodynamics
Non-steroidal anti-inflammatory drug (NSAID), propionic acid derivative. It has analgesic, anti-inflammatory and antipyretic effects. The mechanism of action is associated with inhibition of prostaglandin synthesis at the level of cyclooxygenase-1 and cyclooxygenase-2.
Analgesic effect occurs 30 min after parenteral administration. Duration of analgesic effect after administration of 50 mg is about 4-8 hours.
When combined therapy with opioid analgesics, dexketoprofen significantly (up to 30-45%) reduces the need for opioids.


Management of pain syndrome of different genesis (including postoperative pain, pain from bone metastases, post-traumatic pain, pain from renal colic, algodysmenorrhea, sciatica, radiculitis, neuralgia, toothache);
symptomatic treatment of acute and chronic inflammatory, inflammatory-degenerative and metabolic diseases of the musculoskeletal system (including rheumatoid arthritis, osteoarthritis, spondyloarthritis: ankylosing spondylitis, reactive arthritis, psoriatic arthritis).
The drug is intended for symptomatic therapy, to reduce pain and inflammation at the time of use, does not affect the progression of the disease.


Hypersensitivity to dexketoprofen or other NSAIDs or to any of the excipients included in the preparation (including sulfites);
complete or incomplete combination of bronchial asthma, recurrent nasal and paranasal sinus polyposis and intolerance to acetylsalicylic acid or other NSAIDs (including history);
erosive-ulcerative lesions of the gastrointestinal tract and duodenum;
gastrointestinal bleeding in the history, other active bleeding (including suspected intracranial bleeding), anticoagulant therapy;
inflammatory bowel disease (ulcerative colitis, Crohn’s disease) in the acute stage;
severe liver function disorders (10-15 points on the Child-Pugh scale);
progressive kidney disease, severe renal impairment (creatinine clearance less than 30 ml/min);
confirmed hyperkalemia;
decompensated heart failure;
period after aortocoronary bypass surgery;
hemophilia and other blood clotting disorders;
Pregnancy, breastfeeding;
children and adolescents under 18 years of age.
Dexketoprofen (Flamadex) is contraindicated for neuroaxial (epidural or intrathecal) administration due to the ethanol contained in the drug.


Dosage and administration
  • Intramuscularly (deeply, slowly), intravenously by jetting (slowly for at least 15 seconds) or dropwise (10-30 minutes).
  • The recommended dose for adults is 50 mg every 8-12 hours. If necessary, the drug may be administered repeatedly at 6-hour intervals. Daily dose should not exceed 150 mg. Dexketoprofen (Flamadex) is indicated for short-term use, and treatment with it should be limited to the period of acute symptoms (not more than 2 days).
  • Impairment of liver function
  • In patients with mild to moderate hepatic impairment (5-9 Child-Pugh scores), the total daily dose should be reduced to 50 mg and frequent monitoring of liver function parameters should be performed. Dexketoprofen (Flamadex) should not be prescribed in patients with severe hepatic impairment.
  • Renal dysfunction
  • For patients with mild renal impairment (creatinine clearance 30-60 mL/min), the daily dose should be reduced to 50 mg. Dexketoprofen (Flamadex) should not be administered to patients with moderate or severe renal impairment (creatinine clearance less than 30 ml/min).
  • Elderly patients
  • Dosage adjustment for elderly patients is usually not required; however, in connection with physiological reduction of renal function, it is recommended to reduce the drug dose: total daily dose is 50 mg for mild renal dysfunction in elderly patients.
  • Rules of preparing solutions
  • To prepare Dexketoprofen (Flamadex) solution for intravenous infusion the contents of one ampoule (2 ml) are diluted in 30-100 ml of 0.9% sodium chloride solution, glucose solution or Ringer’s solution. The solution should be prepared under aseptic conditions, protected from exposure to daylight. Prepared solution should be clear and colorless.