Description
Hydrocortisone ointment Pharmacodynamics
Glucocorticosteroid. It has anti-inflammatory and anti-allergic effect. It reduces inflammatory cellular infiltrates, decreases migration of leukocytes and lymphocytes into the inflamed area. Stabilizes cellular and subcellular, including lysosomal membranes and membranes of mast cells. Reduces immunoglobulin binding to cell surface receptors and inhibits synthesis or release of cytokines (interleukins and interferon) from lymphocytes and macrophages. Reduces the release of arachidonic acid from phospholipids and the synthesis of its metabolites (prostaglandins, leukotrienes, thromboxane). Reduces exudative reaction, helps to reduce capillary permeability. It reduces the severity of early immunological response. It has antimetabolic action and inhibits the development of connective tissue and scarring.
Indications
– Allergic eye diseases (eyelid dermatitis, blepharitis, conjunctivitis, and keratoconjunctivitis);
– Inflammatory diseases of the anterior eye in the absence of corneal epithelial integrity disorders (blepharitis, conjunctivitis and keratoconjunctivitis);
– thermal and chemical burns of the eye (after complete epithelialization of corneal defects);
– Corneal damages caused by penetration of foreign bodies (after complete epithelialization of the cornea).
Contraindications
– Hypersensitivity to hydrocortisone or any other component of the drug;
– Purulent, viral (e.g. epithelial keratitis caused by herpes simplex virus, varicella virus, etc.), tuberculosis, fungal eye diseases;
– glaucoma;
– trachoma;
– vaccination period;
– disorders of the integrity of the membranes of the eye;
– children under 18 years of age.
With caution.
Arterial hypertension, diabetes mellitus.
Application during pregnancy and lactation
Studies on the safety and effectiveness of hydrocortisone during pregnancy and breast-feeding have not been carried out.
There are no definitive data on the penetration into breast milk of glucocorticosteroids when topically applied, but the risk cannot be completely excluded. The use of hydrocortisone in pregnancy and during breastfeeding is possible only when the expected therapeutic effect exceeds the potential risk to the fetus or baby. The duration of use in these cases should not exceed 7-10 days.
Consult a doctor before using Hydrocortisone if you are pregnant or if you suspect that you may be pregnant or plan to become pregnant.
Dosage and administration
- Topically.
- A 1 cm strip of ointment is placed behind the lower eyelid 2-3 times a day. Dosing can be changed to 1-2 times a day if condition improves in the course of treatment.
- During application of eye ointment avoid contact of the tip of the tube with the surface of the skin or conjunctiva.
- The course of treatment is 1-2 weeks. The course of treatment may be prolonged as recommended by the doctor.
- If after treatment there is no improvement or symptoms worsen or new symptoms appear, consult a doctor. Use the drug only according to the indications, the method of administration and in such doses as specified in the instructions for use.
