Hopantenic acid (Gopantam) 250 mg – [50 tablets]

Description

Gopantam Pharmacodynamics
The action of Gopantam® is due to the presence of gamma-aminobutyric acid in its structure and its direct effect on the GABA-receptor-channel complex. The drug has nootropic and anticonvulsant effects. It increases resistance of the brain to hypoxia and toxic substances, stimulates anabolic processes in neurons, combines a moderate sedative effect with a mild stimulating effect, reduces motor excitability, activates mental and physical performance.
Improves gamma-aminobutyric acid metabolism in chronic alcohol intoxication and subsequent ethanol withdrawal.
Causes inhibition of pathologically increased bladder reflex and detrusor tone.

Indications
– Cognitive disorders in organic brain lesions, including those resulting from neuroinfections, traumatic brain injury and neurotic disorders;
– in extrapyramidal hyperkinesias, in patients with hereditary diseases of the nervous system in combination with the ongoing therapy;
– as corrector in side effects of neuroleptic drugs, in neuroleptic extrapyramidal syndrome (hyperkinetic and akinetic), as part of complex therapy in patients with cerebral organic insufficiency in schizophrenia;
– epilepsy with delayed mental processes in complex therapy with anticonvulsants;
– Psycho-emotional overload, decreased mental and physical performance, to improve concentration and memory;
– neurogenic disorders of urination (pollakiuria, imperative urges, imperative urinary incontinence, enuresis);
– children with developmental delays (mental, speech, motor, or a combination thereof), including those resulting from perinatal encephalopathy and children with various forms of infantile cerebral palsy;
– children with hyperkinetic disorders (attention deficit hyperactivity disorder);
– Children with neurosis-like conditions (tics, stuttering, mainly in the clonic form).

Contraindications .
Hypersensitivity to any of the drug components, acute severe kidney disease, pregnancy and lactation, children under 3 years of age.

Dosage and administration

• Inside, 15-30 minutes after a meal.
• A single dose for adults is usually 250-1000 mg, for children 250-500 mg; a daily dose for adults is from 1500 mg to 3000 mg, for children – from 750 mg to 3000 mg.
  The course of treatment is from 1 to 4 months, in some cases up to 6 months. A repeated course of treatment is possible after 3 to 6 months.
• In cognitive disorders with organic brain lesions, including those caused by neuroinfections, craniocerebral injuries and neurotic disorders: 250 mg 3-4 times a day.
  In extrapyramidal hyperkinesias in patients with hereditary diseases of the nervous system in combination with the ongoing therapy: in dosage from 500 mg to 3000 mg per day. The course of treatment is up to 4 months and more.
• As a corrector in case of side effects of neuroleptic agents, in neuroleptic extrapyramidal syndrome (hyperkinetic and akinetic), in combination therapy in patients with cerebral organic insufficiency in schizophrenia: in dose from 500 mg to 1000 mg 3 times a day for adults; in dose from 250 mg to 500 mg 3-4 times a day for children.
• The course of treatment ? 1-3 months.
• In epilepsy with mental retardation in combination therapy with anticonvulsants: adults? in doses from 500 mg to 1000 mg 3 times a day, children? in doses from 250 mg to 500 mg 3-4 times a day.
• The course of treatment should be up to 6 months.
  In psychoemotional overload, decreased mental and physical performance, to improve the concentration and memory: 250 mg 3 times a day.
• In neurogenic disorders of urination: adults? in doses from 500 mg to 1000 mg 2-3 times a day; children? in doses from 250 mg to 500 mg 3 times a day (the daily dose is 25-50 mg/kg). The course of treatment ? 1-3 months.
• For children with various pathologies of nervous system, depending on their age, the drug is recommended in dose of 1000-3000 mg per day. The tactics of preparation administration: dose increasing during 7-12 days, intake at a maximum dose during 15-40 days and gradual dose reducing until Gopantam® cessation during 7-8 days. A break between courses of Gopantam®, as for any other nootropic drug, is 1 to 3 months.
  For children with developmental delay: 500 mg 3-4 times a day. The course of treatment is 2-3 months.
• Children with attention deficit hyperactivity disorder: depending on body weight, the drug is prescribed in an average therapeutic dose of 30 mg/kg per day, morning and afternoon. The optimal dose is determined for each patient individually by selection with a gradual increase in the dose during the first 5-7 days. The course of treatment ? 3-4 months.
• For children with neurosis-like conditions (tics; with stuttering, mainly in clonic form): in dosage from 250 mg to 500 mg 3-6 times a day.
  The course of treatment ? 1-4 months.
  Taking into account the nootropic effect of the drug, it is preferably taken in the morning and afternoon hours (before 5 p.m.).
• The drug is used in children over 3 years old. At an earlier age, it is recommended to take the drug in pediatric form.