Drotaverine (Doverine) 40 mg – [48 tablets]

Description

Doverin Pharmacodynamics
Myotropic antispasmodic, isoquinoline derivative. It inhibits phosphodiesterase IV, which leads to accumulation of intracellular cyclic adenosine monophosphate and consequently to inactivation of myosin light chain kinase, resulting in relaxation of smooth muscles.
Regardless of the type of autonomic innervation, drotaverine acts on smooth muscles in the gastrointestinal tract, biliary, urogenital and vascular systems. In myocardium and vessels, the enzyme hydrolyzing cyclic adenosine monophosphate is phosphodiesterase III, which explains the absence of serious cardiovascular side effects and low therapeutic effect on the cardiovascular system.

Indications
– Smooth muscle spasms associated with diseases of the biliary tract (cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, papillitis);
-spasms of the smooth muscles of the urinary tract (nephrolithiasis.urethrolithiasis, pyelitis, cystitis, bladder tenesm). As adjuvant therapy:
– In spasms of the smooth muscles of the gastrointestinal tract (gastric and duodenal ulcer, gastritis, cardiac and gatekeeper spasms, enteritis, colitis, spastic colitis with constipation and mucous colitis with flatulence);
– tensor headache;
– In gynecological disorders (dysmenorrhea).

Contraindications
Hypersensitivity to the active substance or any of the ingredients, severe renal or hepatic failure, severe heart failure (low cardiac output syndrome), lactation, children under 18 years of age. Do not take people with lactose intolerance, lactase deficiency or glucose-galactose malabsorption.
With caution – in arterial hypotension, marked atherosclerosis of the coronary arteries, prostatic hyperplasia, glaucoma, pregnancy.

How to use and dosages.

• Inside. 40-80 mg (1-2 tablets) 2 to 3 times per day in adults.