Desloratadine (Lordestin) 5 mg – [10 tablets]

Description

Lordestin Pharmacodynamics
Long-acting antihistamine drug. It is the primary active metabolite of loratadine. Inhibits the cascade of allergic inflammatory reactions, including the release of pro-inflammatory cytokines, including interleukins IL-4, IL-6, IL-8, IL-13, the release of pro-inflammatory chemokines (RANTES), Superoxide anion production by activated polymorphonuclear neutrophils, eosinophil adhesion and chemotaxis, release of adhesion molecules such as P-selectin, IgE-mediated release of histamine, prostaglandin D2 and leukotriene C4. Thus, it prevents and facilitates the development of allergic reactions, has antipruritic and antiexudative effects, reduces capillary permeability, prevents the development of tissue edema, spasm of smooth muscles.
The drug has no effect on the central nervous system, has practically no sedative effect (does not cause drowsiness) and does not affect the speed of psychomotor reactions. In clinical and pharmacological studies of desloratadine use in the recommended therapeutic dose, no prolongation of the QT interval on ECG was noted.
The action of the drug Lordestin begins within 30 minutes after oral administration and lasts for 24 hours.

Indications
– Allergic rhinitis (elimination or relief of sneezing, nasal congestion, nasal mucus secretion, nasal itching, palate itching, itching and red eyes, lacrimation).
– Urticaria (reduction or elimination of itching, rash).

Contraindications
– Pregnancy.
– Period of breast-feeding.
– Hypersensitivity to desloratadine, other components of the drug, peanuts, soybean oil or loratadine.
– Childhood under 12 years of age.
With caution: severe renal failure.
Administration during pregnancy and lactation
Pregnancy
The drug is contraindicated during pregnancy.
Breast-feeding period
Because desloratadine penetrates into the breast milk, it is contraindicated during breast feeding.

Dosage and administration method

• Orally.
• It is recommended for adults and children 12 years old and over to take once daily in a dose of 5 mg (1 tablet).
• It is recommended to take the drug at a single time of day, regardless of meals, with a small amount of water. The tablet should be swallowed whole, without chewing.
• If seasonal (intermittent) allergic rhinitis (presence of symptoms for less than 4 days per week or less than 4 weeks per year), the course of disease should be evaluated taking into account the anamnesis. If symptoms disappear, treatment may be discontinued and resumed if they reappear.
• In case of year-round (persistent) allergic rhinitis (presence of symptoms for 4 or more days a week or more than 4 weeks a year), the drug should be taken for the entire period of allergen exposure.
• To determine the duration of therapy with the drug, it is necessary to consult the attending physician.
• If after treatment no improvement occurs or symptoms worsen, or new symptoms appear, it is necessary to consult a doctor.
• Use the drug only according to the indications, the route of administration and the doses stated in the instructions.