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Chloropyramine 25 mg – [20 tablets]

$12.42

Anti-allergic agent – h1-histamine receptor blocker

Chloropyramine is used for urticaria, serum sickness, seasonal and year-round allergic rhinitis, allergic conjunctivitis, contact dermatitis, skin itching, acute and chronic eczema, atopic dermatitis, food and drug allergies, allergic reactions to insect bites.

SKU: 63236 Category:

Description

Chloropyramine Pharmacodynamics
Chloropyramine, a chlorinated analog of tripelenamine (pyribenzamine), is a first-generation oto antihistamine drug belonging to the group of ethylenediamine antihistamines.
A blocker of H1-histamine receptors, it has antihistamine and M-cholinolytic effects. This drug also acts on smooth muscles, capillary permeability, and the central nervous system (CNS).
When taken orally, the effect occurs as early as 15-30 minutes, the maximum effect develops within 1 hour and lasts for about 3-6 hours.

 

Indications
Urticaria, serum sickness, seasonal and year-round allergic rhinitis, allergic conjunctivitis, contact dermatitis, skin itching, acute and chronic eczema, atopic dermatitis, food and drug allergies, allergic reactions to insect bites.

 

Contraindications .
Hypersensitivity to chloropyramine and other ingredients of the drug, pregnancy, breast-feeding, children under 3 years of age, lactose intolerance, lactase deficiency or glucose-galactase malabsorption, asthma attack.
Caution
Patients of advanced age as well as patients with liver and/or kidney dysfunction, cardiovascular system, closed-angle glaucoma, urinary retention, prostatic hyperplasia.
Usage during pregnancy and lactation
Pregnancy
There have been no adequately controlled clinical studies of the use of antihistamines in pregnant women. However, cases of retrolental fibroplasia have been described in neonates whose mothers took antihistamines in the last months of pregnancy. Accordingly, the use of the drug during pregnancy is contraindicated.
Breast-feeding
Use of chloropyramine is contraindicated during breastfeeding
If it is necessary to apply the drug during lactation, breastfeeding must be stopped.

 

Dosage and administration

Tablets are taken orally with a meal, without chewing and with plenty of water.

For adults:

1 tablet 3-4 times a day (75-100 mg per day).

Children:

Ages 3 to 6 years: 1/2 tablet (12.5 mg) 2 times daily; daily dose is 25 mg.

Ages 6 to 14 years: 1/2 tablet (12.5 mg) 2 to 3 times a day; daily dose is 25 to 37.5 mg.

Ages 14 to 18 years: 1 tablet (25 mg) 3 to 4 times a day; daily dose is 75 to 100 mg. The dose can be gradually increased in children if the patient has no side effects, but the maximum dose should never exceed 2 mg/kg body weight.

The duration of treatment depends on the nature, symptoms, degree of their manifestation, duration and course of the disease.

Special patient groups

Elderly patients and patients with significant weight deficit

Usage of the drug requires special care as in these patients antihistamines more often cause side effects (dizziness, somnolence, fall of blood pressure (BP)).

Patients with impaired liver function

Dose reduction may be required due to decreased metabolism of chloropyramine in liver disease

Patients with impaired renal function

The drug regimen may need to be changed and the dose decreased due to the fact that chloropyramine is mainly excreted by the kidneys.