Description
Noocil Pharmacodynamics
Citicoline, being a precursor of the key ultrastructural components of the cell membrane (mainly phospholipids), has a broad spectrum of action: it helps restore damaged cell membranes, inhibits the action of phospholipases, prevents the excess formation of free radicals, and also prevents cell death by acting on apoptosis mechanisms. In the acute period of stroke citicoline reduces the volume of brain matter lesions, improves cholinergic transmission. In craniocerebral trauma reduces the duration of post-traumatic coma and severity of neurological symptoms, in addition, it helps reduce the duration of the recovery period.
Ri chronic cerebral hypoxia citicoline is effective in treating cognitive disorders such as memory impairment, lack of initiative, difficulties in performing daily activities and self-care. It increases the level of attention and consciousness and reduces the manifestation of amnesia.
Citicoline is used in the treatment of sensory and motor neurological disorders of degenerative and vascular etiology.
Indications
– Acute phase of ischemic stroke (cerebral infarction) (as part of complex therapy).
– The recovery period of ischemic and hemorrhagic stroke.
– Craniocerebral trauma (CTS): acute (as part of complex therapy) and recovery period.
– Cognitive and behavioral disorders in degenerative and vascular diseases of the brain.
Contraindications .
– Hypersensitivity to any of the components of the drug,
– Patients with marked vagotonia (predominance of the tone of the parasympathetic part of the autonomic nervous system),
– Children under 18 years of age (due to insufficient clinical data).
Pregnancy and lactation:
Sufficient data on the use of citicoline in pregnant women are not available. Although no adverse effects were found in animal studies, during pregnancy the drug is prescribed only in cases when the expected benefits to the mother exceed the potential risk to the fetus.
When prescribing the drug during lactation women should stop breastfeeding, because there is no data about citicoline excretion with breast milk, the risk to the baby can not be completely excluded.
Dosage and administration
- Nootsil® solution for oral administration is administered orally. Before use, the drug may be diluted in a small amount of water (120 ml or ? cup).
- It is taken during or between meals.
- Recommended dosage regimen
- Acute period of ischemic stroke and traumatic brain injury (TBI):
1000 mg (10 ml) every 12 hours. Duration of treatment at least 6 weeks. - Recovery period of ischemic and hemorrhagic strokes, recovery period of CHT, cognitive and behavioral disorders in degenerative and vascular diseases of the brain:
- 500-2000 mg daily (5-10 ml 1-2 times a day). Dosage and duration of treatment depending on the severity of the disease symptoms.
- Elderly patients
No dosage adjustment is required when prescribing the drug in elderly patients.
