Description
Dibasol Pharmacodynamics
It has antispasmodic effect on smooth muscles of blood vessels and internal organs. Lowers BP by reducing cardiac output and dilating peripheral vessels. Hypotensive activity of bendazole is very moderate and the effect is short-lived.
Causes short dilation of cerebral vessels.
Facilitates synaptic transmission in the spinal cord.
Immunostimulatory activity is associated with regulation of the ratio of cGMP and cAMP concentrations in immune cells (increases cGMP content), which leads to the proliferation of mature sensitized T- and B-lymphocytes, their secretion of mutual regulatory factors, cooperative response and activation of the final effector function of cells.
Indications
Arterial hypertension, hypertensive crisis.
Spasms of the smooth muscles of internal organs (including the stomach, intestines).
Residual effects of poliomyelitis, peripheral palsy of the facial nerve.
Contraindications .
Hypersensitivity to bendazole.
Dosage and administration
- Constipation of hypertensive crisis – v/v or v/m 30-40 mg. Acute course of arterial hypertension with significant pressure increase – in/m by 20-30 mg 2-3, the course of treatment – 8-14 days.
- Orally – 20-50 mg 2-3 3-4 weeks.
- In the treatment of nervous diseases – adults in a dose of 5 mg once / or every other day for 5-10 days, after 3-4 weeks the treatment course is repeated. Further courses are conducted with a break of 1-2 months.
- For children, depending on age, the dose is 1-5 mg once a day.
