Description
Becarbon Pharmacodynamics
Becarbon is a combination drug, which consists of belladonna leaf extract and sodium bicarbonate. The drug has antispasmodic and antacid effects.
Antispasmodic effect is due to the effect of belladonna alkaloids: due to m-cholinoblocking effect the tone of smooth muscle organs (bronchial tree, abdominal organs, etc.) decreases, spasm of intestinal muscles, biliary tract is eliminated, peristalsis, secretion of digestive, salivary and other glands are reduced, positive dromotropic and chronotropic effect is developed,
the pupil dilates (at the same time there may be increase of intraocular pressure), accommodation paralysis is possible. Penetrating through the blood-brain barrier, affects the central nervous system (CNS), excites respiratory center, large doses cause motor and mental disorders, seizures, hallucinogenic phenomena, respiratory paralysis.
Sodium bicarbonate neutralizes free hydrochloric acid of gastric juice (antacid action), due to which it has a protective effect on the mucous membrane of the stomach.
Indications
The drug is used as a symptomatic agent in diseases of the gastrointestinal tract, accompanied by increased secretory function of the stomach and spasms of smooth muscles in order to relieve pain and dyspepsia (hyperacid gastritis, gastric and duodenal ulcer, colic).
Contraindications .
– Hypersensitivity to belladonna or any other component of the drug.
– Diseases of the cardiovascular system in which an increase in heart rate may be undesirable: atrial fibrillation, tachycardia, chronic heart failure, coronary heart disease, mitral stenosis, severe arterial hypertension.
– Gastrointestinal diseases, accompanied by obstruction, hypoacid gastritis.
– Hypertrophy of the prostate gland with violation of the outflow of urine.
– Closed-angle glaucoma.
– Myasthenia gravis.
-Hyperthermia syndrome.
-Thyrotoxicosis.
– Acute bleeding.
– Pregnancy.
– Breast-feeding period.
– Childhood under 18 years of age.
Caution
Caution should be exercised in patients
– With autonomic (autonomic) neuropathy;
– With Down’s disease, cerebral palsy, brain damage;
– with hepatic and renal failure;
– Chronic lung disease, accompanied by low sputum production, which is difficult to excrete, especially in weakened patients;
– with reflux esophagitis, esophageal hernia of the diaphragm combined with reflux esophagitis;
– Inflammatory bowel disease, including nonspecific ulcerative colitis and Crohn’s disease;
– with megacolon;
– With xerostomia (dry mouth).
Administration during pregnancy and lactation
Administration of the drug is contraindicated in I trimester of pregnancy due to teratogenic effect of belladonna alkaloids; it is not recommended in II and III trimester of pregnancy due to the absence of data about safety of administration in this category of patients. There is no data concerning penetration of belladonna alkaloids into breast milk; therefore, it is not recommended to use the drug during breast feeding.
Directions for use and dosages
- Adults inside 30-40 minutes before a meal, 1 tablet 2-3 times a day. The tablet should be swallowed without chewing, and drink plenty of water. It is recommended to use the lowest possible effective dose.
- The highest single dose is 5 tablets, the daily dose is 15 tablets.
- Becarbon is intended for symptomatic short-term use, so the duration of treatment should be chosen individually.
- If symptoms of the disease do not go away within 3-5 days, it is necessary to consult a doctor to decide on the further use of the drug.
