Description
Bacteriophage Staphylococcus aureus Pharmacodynamics
Biological properties. The drug causes specific lysis of Staphylococcus bacteria.
Indications
The drug is used for treatment of furuncles, carbuncles, hydroadenitis, abscesses, purulent complicated wounds infected by Staphylococcus aureus, purulent angina, bronchitis, pleurisy, bursitis, thermal burns, chronic osteomyelitis, phlegmon, tendovaginitis, mastitis, cystitis, cholecystitis. In deeply infiltrated and abscessed staphylococcal sycosis, enterocolitis, etc., as well as for preventive purposes: in freshly infected wounds (abdominal and thoracic cavity operations, street and industrial injuries, etc.).
Contraindications .
Hypersensitivity.
Dosage and administration.
- The drug is used for oral administration (by mouth), rectal administration, applications, irrigations, insertion into the cavities of wounds,
Vagina, uterus, nose, sinuses and drained cavities. The vial with bacteriophage must be shaken and viewed before use. The drug should be clear and without sediment (see instructions). - Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and by taking the drug orally 2-3 times a day on an empty stomach 1 hour before meals from the first day of the disease within 7-20 days (according to clinical indications).
- If chemical antiseptics were used to treat wounds before using bacteriophage, the wound must be thoroughly rinsed with sterile sodium chloride 0.9% solution.
- Depending on the nature of the focus of infection bacteriophage is used:
1. In the form of irrigation, lotions and tamponization up to 200 ml, depending on the size of the affected area. In abscess after removal of purulent contents by puncture, the drug is administered in an amount less than the volume of the removed pus. At osteomyelitis after appropriate surgical treatment 10-20 ml of bacteriophage is injected into the wound.
2. When injected into cavities (pleural, articular and other limited cavities) up to 100 ml, then capillary drainage is left, through which bacteriophage is injected for several days.
3. In cystitis, pyelonephritis, urethritis the drug is taken orally. If bladder cavity or renal pelvis are drained, bacteriophage shall be administered through cystostoma or nephrostoma 1-2 times daily by 20-50 ml into the bladder and 5-7 ml into renal pelvis.
4. In cases of pyo-inflammatory gynecological diseases the drug is injected into the cavity of the vagina or uterus in a single dose of 5-10 ml daily, in cases of colpitis – 10 ml by irrigation or tamponization 2 times a day. Tampons are put for 2 hours.
5. In purulent-inflammatory diseases of ear, throat, nose, the drug is administered in a dose of 2-10 ml 1-3 times a day. Bacteriophage is used for gargling, rinsing, dipping, insertion of soaked turundas (leaving them for 1 hour).
6. In enteric infections, bowel dysbacteriosis drug is taken orally 3 times a day for 1 hour before a meal. A combination of twice-daily oral administration with a single rectal administration of a single dose of bacteriophage in the form of an enema after bowel emptying is possible. - Bacteriophage use in children (up to 6 months).
- When sepsis, enterocolitis of newborns,1 including premature infants,’ bacteriophage is used in the form of high enemas (through a gas tube or catheter) 2-3 times a day in a dose of 5-10 ml. In the absence of vomiting and regurgitation the drug can be administered by mouth. In this case, it is mixed with breast milk. A combination of rectal (as a high enema) and oral (by mouth) administration is possible. The course of treatment is 5-15 days. In recurrent course of the disease it is possible to carry out repeated courses of treatment. To prevent sepsis and enterocolitis in intrauterine infection or danger of nosocomial infections in newborn children bacteriophage is used as enema twice a day for 5-7 days.
- In treatment of omphalitis, pyoderma, infected wounds the drug is used in the form of applications daily twice (gauze napkin wetted with bacteriophage and put on the umbilical wound or on the affected skin area).
