Description
Thoraxol Pharmacodynamics
Ambroxol has secretomotor, secretolytic and expectorant action: it stimulates serous cells of bronchial mucous membrane glands, increases the content of mucous secretion and secretion of surfactant (surfactant) in alveoli and bronchi; it normalizes the disturbed ratio of serous and mucous components of sputum. By activating hydrolyzing enzymes and increasing the release of lysosomes from the clara cells, it reduces the viscosity of sputum. Increases motor activity of the cilia of the atomizing epithelium. Increases the flow and transport of mucus (mucociliary clearance). Increased mucociliary clearance improves sputum discharge and makes it easier to cough.
Indications
Acute and chronic respiratory tract diseases with sputum production: acute and chronic bronchitis, pneumonia, chronic obstructive pulmonary disease, bronchial asthma with sputum retention, bronchiectatic disease
Contraindications
Hypersensitivity to ambroxol or to one of its excipients; phenylketonuria; pregnancy (I trimester); lactation
Childhood under 12 years of age (for dispersible tablets 60 mg)
Caution
Impaired bronchial motor function and increased sputum production (in immobile cilia syndrome), gastric and duodenal ulcer during exacerbation, pregnancy (II – III trimester).
Patients with impaired renal function or severe liver disease should take ambroxol with special caution, observing long intervals between doses of the drug or taking the drug in a smaller dose
Use during pregnancy and breastfeeding
Ambroxol passes through the placental barrier. It is not recommended to use during the first trimester of pregnancy.
If it is necessary to use ambroxol in II – III trimesters of pregnancy, the potential benefit to the mother with possible risk to the fetus should be evaluated.
During breast feeding the drug is contraindicated, because it is excreted with the breast milk.
Directions for use and dosages.
- Inside. The tablets are dissolved in a small amount of water (about 20 ml) to get the suspension, you can also swallow the whole or split it with water. Tablets can be taken regardless of meals.
- Adults and children over 12 years of age: 30 mg (1 tablet of 30 mg or 1/2 tablet of 60 mg) 3 times a day.
- If necessary, to increase the therapeutic effect it is possible to prescribe 60 mg (2 tablets of 30 mg or 1 tablet of 60 mg) 2 times a day.
- Children 6 to 12 years of age: 15 mg (1/2 tablet 30 mg) 2 to 3 times a day, previously dissolved in a small amount of water.
- Children from 2 to 6 years of age: 7.5 mg (1/4 tablet 30 mg) 3 times a day, pre-dissolved in a small amount of water.
- Children under 2 years of age: 7.5 mg (1/4 of a tablet of 30 mg) 2 times a day, pre-dissolved in a small amount of water
- It is not recommended to take ambroxol without a prescription for more than 4-5 days.
