Description
Bronchorus Pharmacodynamics
Mucolytic and expectorant drug. It has secretomotor, secretolytic and expectorant action.
Ambroxol stimulates the motor activity of the cilia of the ciliated epithelium of the bronchial mucosa (mucokinetic or secretomotor action).
Peristaltic contraction along the spiral of ciliated (ciliary) cells of bronchial epithelium removes mucus from the bronchial tree (mucociliary transport or mucociliary clearance). Ambroxol significantly improves mucociliary transport.
Ambroxol stimulates serous cells of glands of bronchial mucosa, increases the content of the mucous component of sputum and normalizes the disturbed ratio of serous and mucous components of sputum. By activating hydrolyzing enzymes and increasing release of lysosomes from Clara cells, it reduces sputum viscosity and its adhesive properties (mucolytic or secretolytic action).
Ambroxol increases synthesis and secretion of surfactant (surfactant) in alveoli and bronchi.
As a result of these mechanisms, viscosity of sputum decreases significantly and its expectoration improves.
When administered orally, the drug takes effect within 30 minutes and lasts for 6-12 hours.
Indications
Acute and chronic respiratory diseases, accompanied by viscous sputum:
– Acute and chronic bronchitis;
– pneumonia;
– Bronchial asthma with sputum retention;
– bronchiectatic disease;
– COPD;
– Treatment and prevention of respiratory distress syndrome.
Contraindications
– Hypersensitivity to the components of the drug;
– I trimester of pregnancy;
– Children under 12 years of age (for use in the form of tablets).
It is used with caution in case of hepatic insufficiency, renal insufficiency, stomach and duodenal ulcer, in II and III trimesters of pregnancy, during lactation (breast-feeding).
Dosage and administration
- The drug is taken orally, with a meal, with a small amount of fluid.
- If necessary, to increase the therapeutic effect, 60 mg (2 tablets) can be administered 2 times.
- In severe cases of the disease, the dose is not reduced during the entire course of treatment.
- Children under 12 years of age are prescribed in syrup form.
- Children aged 5-12 years old are prescribed 15 mg (5 ml syrup, i.e. one full teaspoon) 2-3, aged 2-5 years old – 7.5 mg (2.5 ml syrup, i.e. half a teaspoon) 3, under 2 years old – 7.5 mg (2.5 ml syrup) 2
- The need to use the drug for more than 4-5 days the doctor determines individually.
