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Description
Citramon P tablets Pharmacodynamics
A combination drug containing acetylsalicylic acid, caffeine, paracetamol.
Acetylsalicylic acid has antipyretic and anti-inflammatory effects, reduces pain, especially caused by inflammation, and moderately inhibits platelet aggregation and thrombosis, improves microcirculation in the inflammation.
Caffeine increases reflex excitability of the spinal cord, excites respiratory and vasomotor centers, dilates blood vessels of skeletal muscles, brain, heart, kidneys, reduces platelet aggregation; reduces sleepiness, fatigue, increases mental and physical performance. In this combination, caffeine at a low dose has almost no stimulating effect on the central nervous system, but helps normalize the tone of the brain vessels and accelerate blood flow.
Paracetamol has analgesic, antipyretic and very weak anti-inflammatory effects due to its influence on the thermoregulation center in the hypothalamus and a weak ability to inhibit the synthesis of prostaglandins in peripheral tissues.
Indications
Citramon P tablets are used for:
– Pain syndrome of mild to moderate severity (various genesis): headache, migraine, toothache, neuralgia, myalgia, arthralgia, algodysmenorrhea.
– Fever syndrome: with acute respiratory infections, the flu.
Contraindications
– Hypersensitivity to any of the active and/or auxiliary substances;
– erosive-ulcerative lesions of the gastrointestinal tract (in the acute phase), gastrointestinal bleeding or perforation, peptic ulcer in the anamnesis;
– complete or incomplete combination of bronchial asthma, recurrent nasal and paranasal sinus polyposis and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs) (including a history);
– Hemophilia or other blood clotting disorders;
– hemorrhagic diathesis, hypoprothrombinemia;
– K avitaminosis;
– portal hypertension;
– Severe renal or hepatic insufficiency;
– Chronic heart failure III-IV functional class according to NYHA;
– Grade III arterial hypertension;
– Organic diseases of the cardiovascular system (including acute myocardial infarction, atherosclerosis);
– hypoproteinemia;
– Pregnancy and breastfeeding;
– glaucoma;
– Glucose-6-phosphate dehydrogenase deficiency;
– hyperexcitability, sleep disorders;
– Surgical interventions accompanied by heavy bleeding;
– concomitant use of methotrexate at a dose of more than 15 mg/week or more;
– children under 15 years of age as an analgesic, with febrile syndrome under 18 years of age.
Dosage and administration
- Citramon P tablets are taken orally during or after a meal, with plenty of water when taking each dose.
- With headache, the recommended dose is 1-2 tablets, in case of severe headache, the next dose in 4-6 hours.
- In case of migraine the recommended dose is 2 tablets at the appearance of symptoms, and if necessary, another dose in 4-6 hours.
- For treatment of headache and migraine the drug is used not more than 4 days.
- For pain syndrome 1-2 tablets; average daily dose – 3-4 tablets, maximum daily dose – 8 tablets.
- The drug should not be used for more than 5 days as an analgesic and for more than 3 days as an antipyretic.
- Elderly (over 65 years).
- Caution should be exercised in elderly patients, especially those with low body weight.
- Patients with hepatic or renal impairment
- The effect of hepatic or renal impairment on the drug pharmacokinetics has not been studied. Taking into account the mechanism of action of acetylsalicylic acid and paracetamol, their use may worsen renal or hepatic failure. In this regard, the drug is contraindicated in patients with severe hepatic or renal failure (see section “Contraindications”), and the drug should be used with caution in mild to moderate hepatic and renal failure.
