Description
Prednisolone Pharmacodynamics
Prednisolone has anti-inflammatory, anti-allergic, antipruritic and anti-exudative effects.
It reduces the formation, release and activity of inflammatory mediators (histamine, kinin, lysosomal enzymes). Inhibits cell migration to the site of inflammation; reduces vasodilation and increased vascular permeability in the inflammation focus. Reduces exudation due to vasoconstrictor action.
Suppresses the action of macrophages, target cells, cytokines, which are involved in the development of the reaction in the form of allergic contact dermatitis. Prevents the access of sensitized T-lymphocytes and macrophages to the target cells.
Indications
The drug is used in the complex therapy of inflammatory and allergic skin diseases of non-microbial etiology: urticaria, atonic dermatitis, chronic herpes simplex (circumscribed neurodermitis), eczema, seborrheic dermatitis, lupus erythematosus, simple and allergic dermatitis, toxidermia, erythrodermia, psoriasis, alopecia.
Contraindications
Hypersensitivity to prednisolone or any of the drug components, wound, ulcerative, bacterial, viral, fungal skin lesions, open wounds, trophic ulcers, cutaneous postvaccinal reactions, tuberculosis, syphilis, skin tumors, common acne, pink acne (acute condition is possible), pregnancy, breast-feeding, children under 1 year of age.
If you have one of the above diseases, before using the drug be sure to consult with your doctor.
Pregnancy and lactation:
Glucocorticosteroids pass through the placenta. The drug is contraindicated during pregnancy.
Glucocorticosteroids are excreted with breast milk, therefore breast-feeding should be discontinued for the period of treatment during lactation.
Directions for use and dosages.
- Outwardly.
- The ointment is applied thinly to the affected skin areas 1-3 times a day. Course of treatment depends on the nature of the disease and the effectiveness of therapy, is usually 6-14 days. During the recovery period it is possible to use the drug once a day.
- On areas of denser skin (such as elbows, palms, feet) and places from which it rubs off easily, the ointment can be applied more frequently.
- Occlusive dressings may be used on limited areas to enhance the effect.
