Description
Pentaflucin Daytime Pharmacodynamics
Pentaflucin daily is a combination drug. Pharmacological effects are due to the complex action of the components that make up the drug.
Paracetamol has antipyretic and analgesic effect, blocks cyclooxygenase enzyme type 1 (COX-1) and cyclooxygenase enzyme type 2 (COX-2) mainly in the central nervous system, affecting the pain and thermoregulation centers.
Ascorbic acid – plays an important role in the regulation of redox processes, carbohydrate metabolism, blood coagulation, tissue regeneration, increases the body’s resistance.
Caffeine has psychostimulant (stimulates psychomotor centers of the brain), analeptic effect, increases the analgesic effect of paracetamol, eliminates drowsiness and fatigue, increases physical and mental performance.
Calcium gluconate – is a source of calcium in the body, it has anti-allergic effect (mechanism is unclear), prevents the development of high permeability and fragility of blood vessels, which causes hemorrhagic processes during influenza and acute respiratory viral infections, and also restores the capillary blood circulation.
Rutoside – reduces capillary permeability and fragility, has antioxidant properties.
Indications
Pentaflucin daytime is used in adults for symptomatic treatment of acute respiratory diseases (ARI) and acute respiratory viral infections (ARVI), accompanied by fever, chills, headache and muscle pain.
Contraindications .
Hypersensitivity to the components of the drug, severe hepatic and/or renal insufficiency, blood diseases with tendency to hemorrhage, pregnancy and breast-feeding, closed glaucoma, arterial hypertension, diabetes mellitus, sleep disturbances, epilepsy, hyperoxaluria, hypercalciuria; hypercalcemia; nephrourolithiasis; concomitant use with other drugs containing paracetamol; alcohol intoxication; glucose-6-phosphate dehydrogenase deficiency, childhood age (under 18 years), congenital fructose intolerance, glucose-galactose malabsorption, sugar/isomaltase deficiency.
Dosage and administration
- The contents of one sachet of the drug dissolved in 1/2 cup (125 ml) of hot water (t = 70 ° C) and drink.
- Slight sediment in the glass is allowed.
- Freshly prepared solution should be used. Shake well before use.
- Pentaflucin daily used orally after a meal, 1 sachet 3-4 times a day for 3-5 days.
- The interval between doses of the drug is at least 4 hours.
- Patients with impaired liver function or with Gilbert syndrome should reduce daily dose or increase interval between doses to 8 hours.
- In patients with impaired renal function, the time interval between doses of the drug should be at least 8 hours if creatinine clearance is less than 10 ml/min, at least 6 hours – if creatinine clearance is 10-50 ml/min.
