Description
Paracetamol Pharmacodynamics
Non-narcotic analgesic, has analgesic and antipyretic effects. The drug blocks cyclooxygenase 1 and 2 in the central nervous system, affecting the centers of pain and thermoregulation. In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on cyclooxygenase, which explains the lack of significant anti-inflammatory effect. The drug has no negative effect on water-salt metabolism and mucosa of the gastrointestinal tract.
Indications
Used in children from 3 months to 12 years as:
– antipyretic – to reduce elevated body temperature against a background of colds, influenza and childhood infectious diseases (chickenpox, mumps, measles, rubella, scarlet fever, etc.);
– Painkillers – for toothache, including teething, headache, earache from otitis and sore throat.
For children 2-3 months of age, a single dose may be used to lower the fever after vaccination. If the fever does not go down, a physician should be consulted.
Contraindications
– Individual hypersensitivity to the drug components;
– Sucrose/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption;
– Significant liver and kidney dysfunction
– Age less than 2 months.
Dosage and administration
- The drug is taken orally. The content of 5 ml of the suspension is 120 mg of paracetamol. There are 16 doses of 5 ml in one bottle, 24 doses in 150 ml and 32 doses in 200 ml.
- The drug is taken orally before meals in undiluted form, with plenty of fluid 1-2 hours after meals. The contents of the bottle should be shaken thoroughly before use.
- A single dose of 10-15 mg/kg is used for symptomatic treatment of reactions to vaccination in children aged 2 to 3 months. If necessary, the dose may be repeated, but not earlier than 4 hours later. If the child’s body temperature does not decrease after the second dose, a physician should be consulted.
- Using the drug in patients of this age category for other indications is possible only on the doctor’s recommendation!
- For children over 3 months old a single dose is 10-15 mg/kg of body weight, 3-4 times a day. If necessary, you can give the child the recommended dose every 4-6 hours, but no more than 4 doses within 24 hours.
- The maximum daily dose is not more than 60 mg/kg body weight.
- The recommended dose should not be exceeded. Maximum duration of drug administration without physician’s consultation is 3 days. In the future, as well as in the absence of therapeutic effect, it is necessary to consult a doctor.
- For precise dosing of the drug, depending on the proposed package, use a measuring spoon or measuring syringe enclosed in the package.
