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Acetysalacyl acid, paracetamol, coffeine (Ascophen Ultra) – [20 tablets]


Analgesic non-narcotic drug (nsaid + analgesic non-narcotic drug + psychostimulant)

SKU: 61020 Category:


Ascophen Pharmacodynamics
A combination drug containing paracetamol, acetylsalicylic acid and caffeine.
Acetylsalicylic acid has antipyretic and anti-inflammatory effects, relieves pain, especially caused by inflammation, and inhibits platelet aggregation and thrombosis, improves microcirculation in the inflamed area.
Caffeine increases reflex excitability of the spinal cord, excites respiratory and vasomotor centers, dilates blood vessels of skeletal muscles, brain, heart, kidneys, reduces platelet aggregation; reduces sleepiness, fatigue, increases mental and physical performance. In this combination, caffeine at a low dose has almost no stimulating effect on the central nervous system, but increases the tone of the cerebral vessels and helps accelerate blood flow.
Paracetamol has analgesic, antipyretic and very weak anti-inflammatory effects due to its influence on the thermoregulation center in the hypothalamus and a weak ability to inhibit the synthesis of prostaglandins (Pg) in peripheral tissues.

Pain syndrome of moderate to mild intensity of different origin in adults and children over 15 years:
– headache;
– migraine;
– toothache;
– neuralgia;
– arthralgia;
– myalgia;
– algodysmenorrhea (pain during menstruation).
Fever syndrome in adults: in acute respiratory diseases, influenza.

Contraindications .
– Hypersensitivity to the main or auxiliary components of the drug;
– erosive-ulcerative lesions of the gastrointestinal tract (GIT) (in the acute phase), gastrointestinal bleeding or perforation, peptic ulcer in the history;
– complete or incomplete combination of bronchial asthma, recurrent nasal and paranasal sinus polyposis and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including history);
– hemophilia and other blood clotting disorders; hemorrhagic diathesis, hypoprothrombinemia;
– vitamin K deficiency;
– portal hypertension;
– Severe renal or hepatic insufficiency;
– Chronic heart failure III-IV functional class according to NYHA;
– Grade III arterial hypertension;
– pregnancy;
– Breast-feeding period;
– glaucoma;
– Glucose-6-phosphate dehydrogenase deficiency;
– High nervous excitability, sleep disturbances;
– Surgical interventions accompanied by heavy bleeding;
– children under 15 years of age as an analgesic, with febrile syndrome under 18 years of age;
– concomitant administration of methotrexate at a dose greater than 15 mg/week.

Dosage and administration

  • The drug is taken orally with or after meals.
  • For pain relief in adults and children over 15 years: 1 tablet every 4-6 hours.
    At the first signs of migraine two tablets are taken.
  • In febrile syndrome in adults: 2 tablets every 6 hours.
  • The average daily dose is 3-4 tablets a day, the maximum daily dose is 6 tablets a day.
    After taking 2 tablets the relief of headache and other types of pain usually comes quickly – after 15 minutes, with migraine the relief usually comes in 30 minutes.
  • In pain syndrome, the drug should not be taken for more than 5 days without consulting a doctor. For headache and migraine the drug is used not longer than 4 days. In case of fever syndrome the drug should not be taken for more than 3 days without consulting a physician.
  • Elderly (over 65 years). Caution should be exercised in elderly patients, especially in low body weight.
  • Patients with hepatic and renal insufficiency. The effect of hepatic or renal impairment on the drug pharmacokinetics has not been studied. Taking into account the mechanism of action of acetylsalicylic acid and paracetamol, their use may aggravate renal or hepatic failure. Because of this, the drug is contraindicated in patients with severe hepatic or renal insufficiency and should be used with caution in case of mild to moderate hepatic and renal insufficiency.