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Trimebutine (Neobutin) 100 mg – [10 tablets]


Antispasmodic drug

SKU: 62210 Category:


Neobutin Pharmacodynamics
Trimebutine, acting on the enkephalinergic system of the intestine, is a regulator of its peristalsis. Acting on peripheral ?-, ?- and ? receptors, including those located directly on the smooth muscles throughout the gastrointestinal tract (GIT), it regulates motility without affecting the central nervous system. Thus, trimebutine restores normal physiological activity of the intestinal muscles in various GI diseases associated with motility disorders.
Normalizing visceral sensitivity, trimebutine provides analgesic effect in abdominal pain syndrome.

Adults and children from 3 years.
Symptomatic treatment of abdominal pain and discomfort, cramps, bloating sensations (flatulence), bowel motor disorders with changes in stool frequency (diarrhea, constipation or alternation), changes in stool consistency associated with irritable bowel syndrome.
Postoperative intestinal obstruction.

Hypersensitivity to trimebutyn maleate and other components included in the drug.
Childhood age under 3 years (for this dosage form).
Lactose intolerance, lactase deficiency, glucose-galactose malabsorption.
Administration during pregnancy and lactation
Pregnancy. No data on teratogenicity and embryotoxicity of trimebutine were found in experimental studies. Nevertheless, due to lack of necessary clinical data, the use of Neobutin® during pregnancy is contraindicated.
Breast-feeding period. Neobutin® is not recommended for use during breast-feeding because of the lack of reliable clinical data confirming the safety of the drug during this period. If it is necessary to apply trimebutine during breastfeeding, breastfeeding should be stopped.

Dosage and administration

  • Orally, before meals.
  • Adults and children over 12 years of age: 100-200 mg 3 times daily.
  • To prevent relapse of irritable bowel syndrome after previous treatment, it is recommended to continue treatment at a dose of 300 mg per day for 12 weeks during remission.
  • Children aged 5-12 years: 50 mg 3 times per day.
  • Children aged 3-5 years: 25 mg 3 times per day.