Description
Diuver Pharmacodynamics
Torasemide is a “loop” diuretic. Maximum diuretic effect develops 2-3 hours after oral administration. The main mechanism of action of the drug is caused by the reversible binding of thoracemide to the sodium/chloride/potassium ion transporter, located in the apical membrane of the thick segment of the ascending loop of Genle, which results in reduction
or completely inhibits sodium ion reabsorption and decreases intracellular fluid osmotic pressure and water reabsorption. It blocks myocardial aldosterone receptors reduces fibrosis and improves myocardial diastolic function.
Torasemide causes hypokalemia to a lesser extent than furosemide, but it is more active and its effect is more prolonged.
The use of thoracemide is the most reasonable choice for long-term therapy.
Indications
– Oedema syndrome of different genesis, including chronic heart failure, liver, lung and kidney diseases;
– arterial hypertension.
Contraindications
Hypersensitivity to thorasemide or to any of the drug components; in patients with allergy to sulfonamides (sulfonamide antimicrobials or sulfonylureas); renal failure with anuria; hepatic coma and precoma; marked hypokalemia; marked hyponatremia; hypovolemia (with or without arterial hypotension) or dehydration; acute glomerulonephritis; decompensated aortic and mitral stenosis, hypertrophic obstructive cardiomyopathy; increased central venous pressure (over 10 mm Hg). st); hyperuricemia; under 18 years of age; lactation; lactose intolerance, lactase deficiency or glucose-galactose malabsorption.
Dosage and administration
- Orally, once a day, after breakfast, with plenty of water.
- Oedema syndrome of various genesis, including chronic heart failure, liver, lung and kidney diseases.
- Usual therapeutic dose is 5 mg orally once a day. If necessary, the dose should be gradually increased to 20-40 mg once a day, in some cases, to 200 mg per day. The drug is indicated for a prolonged period or until the oedema has disappeared.
- Arterial hypertension
- The initial dose is 2.5 mg (1/2 tablet of 5 mg) once a day. If necessary, the dose may be increased to 5 mg once daily.
- No dose adjustment is required in elderly patients.
