Description
Tolizor Pharmacodynamics
Tolperizone hydrochloride is a myorelaxant of central action. It has membrane stabilizing, local anesthetic effect, inhibits conduction of nerve impulses in primary afferent fibers and motor neurons, which leads to blocking of spinal mono- and polysynaptic reflexes. Presumably, tolperizone mediates the blocking of mediator release by inhibition of calcium ion entry into synapses. Inhibits the conduction of excitation along the reticulospinal pathway in the brainstem. Regardless of the effect on the central nervous system (CNS), it increases the peripheral blood supply. This effect is not related to the effect of the drug on the central nervous system and may be due to the weak antispasmodic and antiadrenergic effect of tolperizone.
Lidocaine hydrochloride has local anesthetic effect and has no systemic action when dosed according to the instructions.
Indications
– Symptomatic treatment of spasticity in adults due to stroke.
– Moderate to severe myofascial pain syndrome (including muscle spasm in dorsopathies).
Contraindications
– Hypersensitivity to the components of the drug, including lidocaine;
– severe myasthenia gravis;
– Pregnancy and breast-feeding;
– childhood and adolescence under 18 years of age.
Caution
The drug should be used with caution in renal and hepatic insufficiency. No dosage adjustment is required.
Administration during pregnancy and breast feeding.
The drug administration is possible only in case when the supposed benefit for mother overweights the potential risk for fetus and child. If it is necessary to prescribe the drug during lactation, breastfeeding should be discontinued.
Dosage and administration method
Daily intramuscularly – 100 mg (1 ml) 2 times per day or intravenously – 100 mg (1 ml) 1 time per day in adults.
