Thioctic acid (Thiolepta) 600 mg – [30 tablets]

Thioct (alpha-lipoic acid) – endogenous antioxidant of direct (binds free radicals) and indirect action. It is a coenzyme of decarboxylation reactions of alpha-keto acids. It helps reduce plasma glucose concentration and increases glycogen concentration in the liver, also reduces insulin resistance, participates in the regulation of carbohydrate and lipid metabolism, and stimulates cholesterol metabolism.

Due to its antioxidant properties, thioctic acid protects cells from damage by breakdown products, reduces the formation of end products of progressive glycosylation of proteins in nerve cells in diabetes,

improves microcirculation and endoneural blood flow, increases the physiological content of the antioxidant glutathione. Contributing to a decrease in plasma glucose concentration, affects the alternative metabolism of glucose in diabetes, reduces the accumulation of pathological metabolites in the form of polyols and thereby reduces the swelling of nervous tissue. Due to its involvement in fat metabolism, thioctic acid increases the biosynthesis of phospholipids, particularly phosphoinositides, thus improving the damaged structure of cell membranes, normalizes energy metabolism and nerve impulse conduction. Thioctic acid eliminates toxic effects of alcohol metabolites (acetaldehyde, pyruvic acid), reduces the excessive formation of free oxygen radical molecules, reduces endoneural hypoxia and ischemia, weakening manifestations of polyneuropathy in the form of paresthesia, burning sensation, pain and numbness of the extremities.

Thus, thioctic acid has antioxidant, neurotrophic, hypoglycemic effect, improves lipid metabolism.

-diabetic polyneuropathy;

-alcoholic polyneuropathy.

Contraindications .

-Hypersensitivity to thioctic acid and any of the excipients of the drug;

Pregnancy, breast-feeding (there is insufficient experience in using the drug);

-Children under 18 years of age (efficacy and safety of use have not been established).

Administration during pregnancy and lactation

The use of thioctic acid during pregnancy is contraindicated due to the lack of sufficient experience in its use.

Studies of reproductive toxicity have not revealed any risk of fetal development or any embryotoxic properties of the drug.

It is unknown whether thioctic acid penetrates into the mother’s milk. If it is necessary to apply the drug during breastfeeding, breastfeeding should be stopped.