Description
Termicon spray Pharmacodynamics
Antifungal drug for topical use, which has a broad spectrum of antifungal activity. In low concentrations, terbinafine has fungicidal effect against dermatophytes (Trychophyton rubrum, T. mentagrophytes, T. verrucosum, T. violaceum, T. tonsurans, Microsporum canis, Epidermophyton floccosum), molds, certain dimorphs (Pityrosporum orbiculare) and yeasts (mainly candida albicans).
Activity against yeast fungi, depending on their species, may be fungicidal or fungistatic.
Terbinafine specifically alters the early stage of sterol biosynthesis occurring in fungi. This leads to ergosterol deficiency and intracellular accumulation of squalene, which causes cell death of the fungus.
Terbinafine works by inhibiting the squaleneepoxidase enzyme located on the cell membrane of the fungus.
Terbinafine has no effect on the cytochrome P450 system in humans and, therefore, on the metabolism of hormones or other drugs.
Indications
Prevention and treatment of fungal skin infections, including:
– Mycoses of the feet (“fungus” of the foot),
– inguinal epidermophytosis,
– Fungal lesions of smooth skin of the body caused by dermatophytes (trichophytosis, microsporia, epidermophytosis, rubrophytosis).
Lichen multicolor caused by dimorphic fungi.
Diaper rash caused by mold fungi.
Contraindications
Hypersensitivity to terbinafine or to the excipients that make up the drug, children under 18 years of age.
How to use and dosages
- Outwardly.
- Adults. Termikon ® spray can be used 1 or 2 times a day, depending on the indication. Before using the drug thoroughly clean and dry the affected areas of the skin.
- To ensure an even spray of the contents, make a few brief pressings on the spray nozzle beforehand.
- The drug is applied to the affected areas of the skin and adjacent healthy skin in sufficient quantities to moisten them.
- Frequency of application of the drug and duration of treatment:
- – dermatomycosis of the trunk, shins: once a day for 1 week;
- – Dermatomycosis of the feet: once a day for 1 week;
- – Colored lichen: 2 times a day for 1 week;
- – inguinal epidermophytosis, diaper rash caused by mold fungi: 1 time per day for 1 week.
