Description
Streptocid ointment Pharmacodynamics
Antibacterial agent of a broad spectrum of action. Sulfonamide (streptocid) is one of the first representatives of the chemotherapeutic agents of the sulfonamide group. It has a bacteriostatic effect. The mechanism of action is due to competitive antagonism with PABA and competitive inhibition of the enzyme dihydropteroatsinthetase. This leads to disruption of dihydrofolic acid and then tetrahydrofolic acid synthesis and, as a result, to disruption of nucleic acid synthesis.
Sulfonamide is active against Gram-positive and Gram-negative cocci, Escherichia coli, Shigella spp., Vibrio cholerae, Haemophilus influenzae, Clostridium spp., Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, and against Chlamydia spp., Actinomyces spp., Toxoplasma gondii.
Indications
Infectious-inflammatory diseases caused by sulfonamide-sensitive microorganisms, including tonsillitis, hornblain, cystitis, furunculosis, infectious diseases of the skin and mucous membranes, rosaceous acne.
Contraindications .
Severe renal failure, blood diseases, glucose-6-phosphate dehydrogenase deficiency, acute porphyria, pregnancy, lactation, hypersensitivity to sulfonamides.
Directions for use and dosage
Externally, applied directly to the affected surface.
