Description
Remaxol Pharmacodynamics
REMAXOL® is a balanced infusion solution with hepatoprotective effect.
The drug accelerates the transition of anaerobic processes into aerobic ones, improves energy supply of hepatocytes, increases macroerg synthesis, increases resistance of hepatocyte membranes to lipid peroxidation, restores the activity of antioxidant defense enzymes.
REMAXOL® decreases cytolysis, which is manifested by the decrease of indicator enzymes: aspartate aminotransferases, alanine aminotransferases.
REMAXOL® promotes reduction of bilirubin and its fractions, improves excretion of direct bilirubin into bile. Reduces activity of hepatocyte excretory enzymes – alkaline phosphatase and gamma-glutamyl transpeptidase, promotes oxidation of cholesterol into bile acids.
Indications
Intrahepatic cholestasis syndrome in chronic diffuse liver diseases (alcoholic liver disease, toxic liver injury, liver fibrosis and sclerosis, fatty liver degeneration, chronic hepatitis).
Other liver function abnormalities due to acute or chronic liver damage (toxic, alcoholic, viral, drug-induced hepatitis).
Contraindications .
Individual intolerance to the components of the drug, pregnancy, breast-feeding, children.
Caution
In nephrolithiasis, gout, hyperuricemia.
Administration during pregnancy and lactation
Preclinical studies have not shown direct or indirect effects on pregnancy, embryo/fetal development, delivery or postnatal development. No controlled studies have been conducted on the use of the drug during pregnancy. REMAXOL® should not be administered during pregnancy. Refrain from breastfeeding when REMAXOL® is prescribed to a woman.
Dosage and administration method
- REMAXOL® is administered intravenously by drop infusion at a rate of 40-60 drops (2-3 ml) per minute. In intrahepatic cholestasis syndrome in chronic diffuse liver diseases the drug is given as 400 ml 1 time per day during 10 days.
- In other liver dysfunctions caused by acute or chronic liver injury the drug is administered in daily dose of 400 to
- 800 ml over 3-12 days depending on severity of the disease.
