Description
Slabilen Pharmacodynamics
Active substance – sodium picosulfate is a laxative of triarylmethane group. As a local laxative sodium picosulfate after bacterial cleavage in the large intestine has a stimulating effect on the mucosa of the large intestine, increasing peristalsis, contributes to accumulation of water and electrolytes in the large intestine. This leads to stimulation of the act of defecation, reduced evacuation time and softening of stools. The action occurs 10-12 hours after intake.
Sodium picosulfate as a laxative acting at the level of the large intestine stimulates the natural process of evacuation of contents from the lower parts of the gastrointestinal tract. Therefore, sodium picosulfate has no effect on digestion or absorption of caloric foods or essential nutrients in the small intestine.
Indications
As a laxative in the following cases:
constipation caused by atony and hypotonia of the large intestine (including the elderly, bedridden patients, after surgery, after childbirth, during breastfeeding);
– constipation caused by taking medications;
– To regulate stools with hemorrhoids, proctitis, anal fissures (to soften the consistency of feces);
– Gallbladder disease, irritable bowel syndrome with predominant constipation;
– constipation due to intestinal dysbacteriosis, a violation of the diet.
Contraindications
-intestinal obstruction or obstructive bowel disease
-Acute abdominal diseases or severe abdominal pain that may be accompanied by nausea, vomiting, fever, including appendicitis
-Acute inflammatory bowel disease
-Hypersensitivity to sodium picosulfate or other drug components
-Severe dehydration
-Lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
-Children under 10 years of age (for this dosage form, children under 10 years should take Slabilen® in other dosage form – drops for oral administration)
-Pregnancy (first trimester)
Caution
-II and III trimesters of pregnancy
-Period of lactation
Dosage and administration
- Inside, the whole, without breaking, with a little water, before going to bed. Recommended daily dosage for adults and children over 10 years of age – 5 mg (1 tablet of 5 mg) 1 time per day, in case of firm constipation – up to 10 mg (2 tablets of 5 mg) 1 time per day. Depending on the effect obtained, the dose is increased or decreased during subsequent administration. Maximal daily dose is 15 mg (3 tablets of 5 mg or 2 tablets of 7.5 mg or 1 tablet of 15 mg).
- It is recommended to start with the lowest dose. In order to achieve regular stools, the dose may be increased to the maximum recommended dose. The maximum recommended daily dose should not be exceeded.
- To obtain a laxative effect in the morning hours, the drug should be taken the night before.
