Description
Gastrostat Pharmacodynamics
Rebamipid increases prostaglandin E2 (PGE2) content in gastric mucosa and increases PGE2 and GI2 content in gastric juice content. It has a cytoprotective effect on the gastric mucosa under the damaging effects of ethanol, acids and alkalis, acetylsalicylic acid. It promotes activation of enzymes that accelerate biosynthesis of high molecular weight glycoproteins, and increases the content of mucus on the surface of the stomach wall. Helps improve blood supply to the gastric mucosa, activates its barrier function, activates alkaline secretion of the stomach, increases proliferation and metabolism of gastric epithelial cells, cleanses the mucosa of hydroxyl radicals and suppresses superoxides, produced by polymorphonuclear leukocytes and neutrophils in the presence of Helicobacter pylori, protects the gastric mucosa from damage by bacteria, has gastroprotective effect when the mucosa is affected by nonsteroidal anti-inflammatory drugs (NSAIDs).
Indications
Peptic ulcer. Chronic gastritis with increased acid-forming function of the stomach in the acute stage, erosive gastritis. Prevention of mucosal damage against the background of taking nonsteroidal anti-inflammatory drugs. Can be used as part of combination therapy.
Contraindications
Individual intolerance to rebamipide or other components of the drug.
Pregnancy.
Period of lactation.
Children under 18 years of age.
Caution
It is recommended to be cautious when prescribing Rebamipide for elderly patients because of possible occurrence of hypersensitivity to the drug.
Administration during pregnancy and breast feeding period
The safety of rebamipide administration during pregnancy has not been proven. Do not use during pregnancy. As rebamipide penetrates into breast milk, it is necessary to stop breast-feeding or to decide on artificial feeding in case it is necessary to use rebamipide during breast-feeding.
Dosage and administration method
- Inside, 1 tablet 3 times a day with plenty of fluid. The course of treatment is 2-4 weeks, if necessary, can be extended up to 8 weeks. The drug has no specificity of action at the first dose or at its cancellation.
- If you miss one dose, take the next dose of the drug at the prescribed time, do not take a double dose of the drug.
