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Pyridoxine, benfotiamine (Citipigam compositum) – [30 tablets]

$12.42

B vitamins

SKU: 63337 Category:

Description

Citipigam Compositum Pharmacodynamics
Benfothiamine, a fat-soluble derivative of thiamine (vitamin B1), is phosphorylated in the body to the biologically active coenzymes thiamine diphosphate and thiamine triphosphate. Thiamine diphosphate is a coenzyme of pyruvate decarboxylase. 2-oxyglutarate dehydrogenase and transketolase, thus participating in the pentose phosphate cycle of glucose oxidation (in the transfer of the aldehyde group).
Phosphorylated form of pyridoxine (vitamin B6) – pyridoxalphosphate – is a coenzyme of several enzymes affecting all stages of non-oxidative metabolism of amino acids. Pyridoxal phosphate is involved in the decarboxylation of amino acids and therefore in the formation of physiologically active amines (e.g., adrenaline, serotonin, dopamine, tyramine). Pyridoxal phosphate is involved in anabolic and catabolic processes (e.g. it is a coenzyme of such transaminases as glutamate oxalocetate transaminase, glutamate pyruvate transaminase, GABA, a-ketoglutarate transaminase) as well as in various reactions of amino acid breakdown and synthesis. Vitamin B6 is involved in 4 different steps of tryptophan metabolism.

 

Indications
Neurological diseases with confirmed vitamin B1 and B6 deficiency.

 

Contraindications .
Hypersensitivity to thiamine, benfotiamine, pyridoxine and / or any excipient in the preparation.
Period of pregnancy and breast-feeding.
Age under 18 years (due to the lack of clinical data on the effectiveness and safety of the combination of benfotiamine and pyridoxine).
Administration during pregnancy and breastfeeding
Application of Citipigam compositum during pregnancy and lactation is contraindicated.

 

Dosage and administration
  • Inside.
  • The tablet should be swallowed with plenty of fluid.
  • If otherwise is not prescribed by the attending physician, an adult patient should take 1 tablet a day.
  • In acute cases, after doctor’s consultation, the dose may be increased to 1 tablet 3 times a day. After 4 weeks of treatment the physician should decide whether to continue taking the drug in an increased dose and consider reducing the increased dose of vitamins B1 and B6 to 1 tablet per day. If possible, the dose should be reduced to 1 tablet daily to reduce the risk of vitamin B6-associated neuropathy.
  • If there is no improvement after treatment or if symptoms worsen or new symptoms appear, it is necessary to consult a physician. Use Citipigam compositum only according to the method of use and in such doses as specified in the instructions.