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Progesterone (Oxyprogesterone Capronate) oily injection 125 mg/ml 1 ml – [10 ampoules]


Progestogen. Infertility due to insufficiency of the corpus luteum

SKU: 62289 Category:


Oxyprogesterone Capronate Pharmacodynamics
Oxyprogesterone capronate is an analogue of the corpus luteum hormone (progesterone). Chemically, it differs from progesterone in that it contains a capronic acid residue in position 17. Being an ester of hydroxyprogesterone, it is metabolized slower than progesterone (it has a more prolonged effect). After a single injection of the oil solution in m/m, its effect lasts from 7 to 14 days. Its biological properties are similar to those of progesterone. Binding with receptors on the surface of the target organ cells, it penetrates into the nucleus, where, by activating DNA, it stimulates RNA synthesis. It promotes the transition of the uterine mucosa from the phase of proliferation caused by the follicular hormone to the secretory phase, and after fertilization it creates the necessary conditions for implantation and development of the fertilized egg. It reduces the excitability and contractility of uterine muscles and fallopian tubes, stimulates the development of mammary gland terminal elements.

Conditions associated with insufficiency of the corpus luteum: a threatened and incipient miscarriage (prevention and treatment), amenorrhea (primary and secondary), dysfunctional uterine bleeding.

Hepatitis, liver failure, breast cancer and reproductive organs, a tendency to thrombosis. Disease CCS, arterial hypertension, CVD, diabetes, bronchial asthma, epilepsy, migraine, depression, hyperlipoproteinemia, ectopic pregnancy, lactation.

Dosage and administration

  • Intramuscularly. To prevent and treat threatened and started miscarriage, it is administered by 0.125-0.25 g (1-2 ml of 12.5% solution) once a week. It is used only in the first half of pregnancy.
  • At amenorrhea (primary, secondary) it is appointed directly after discontinuation of estrogenic drugs on 0.25 g, once, or in 2 injections.
  • For the treatment of dysfunctional uterine bleeding the drug is less convenient than progesterone because its effect is slow, but it can be used to normalize the cycle: 0.0625-0.125 g (0.5-1 ml of 12.5% solution) on days 20-22 of the cycle.