Paracetamol, naproxen, caffeine (Pentalgin) – [12 tablets]

Combined drug, has analgesic, anti-inflammatory, antispasmodic, antipyretic action.

Paracetamol is a non-narcotic analgesic, has antipyretic and analgesic effect, due to the blockade of cyclooxygenase in the central nervous system and effects on the pain and thermoregulation centers.

Naproxen is a non-steroidal anti-inflammatory drug that has anti-inflammatory, analgesic and antipyretic effect due to non-selective inhibition of cyclooxygenase activity that regulates prostaglandin synthesis.

Caffeine causes dilation of blood vessels in skeletal muscles, heart, kidneys; it increases mental and physical performance, eliminates fatigue and sleepiness; it increases permeability of histohematic barriers and increases bioavailability of non-narcotic analgesics, thus enhancing therapeutic effect. It has a tonic effect on the blood vessels of the brain.

Drotaverine has a myotropic antispasmodic effect due to inhibition of phosphodiesterase IV, acts on smooth muscles in the gastrointestinal tract, biliary tract, genitourinary and vascular systems.

Pheniramine is a blocker of H1-histamine receptors. It has antispasmodic and mild sedative effects, reduces the phenomena of exudation, and enhances the analgesic effect of paracetamol and naproxen.

Pain syndrome of different genesis, including joint and muscle pain, radiculitis, menstrual pain, neuralgia, toothache and headache (including headache caused by cerebral vasospasm).

Pain syndrome associated with spasm of smooth muscles, including chronic cholecystitis, cholelithiasis, post-cholecystectomy syndrome, renal colic.

Post-traumatic and post-operative pain syndrome, including those accompanied by inflammation.

Colds accompanied by a febrile syndrome (as symptomatic therapy).

Hypersensitivity to the drug components, erosive-ulcerative lesions of the gastrointestinal tract (in the acute phase), gastrointestinal bleeding, complete or incomplete bronchial asthma, recurrent polyposis of the nose and sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs, including a history, severe hepatic and/or renal failure, inhibition of medullary hematopoiesis, conditions after coronary artery bypass surgery; severe organic diseases of the cardiovascular system (including acute myocardial infarction), paroxysmal tachycardia, frequent ventricular extrasystoles, severe arterial hypertension, hyperkalemia, children under 18 years of age, pregnancy and lactation.