Description
Paracetamol Pharmacodynamics
Paracetamol has analgesic, antipyretic and very weak anti-inflammatory activity, due to its influence on the thermoregulation center in the hypothalamus and a weak ability to inhibit the synthesis of prostaglandins
in peripheral tissues. The absence of blocking effect on prostaglandin synthesis in peripheral tissues determines the absence of its negative effect on water-salt metabolism (retention of sodium and water ions) ts mucosa of the gastrointestinal tract.
Indications
Antipyretic in acute respiratory infections and other inflammatory diseases, accompanied by fever.
Pain reliever for mild to moderate pain: arthralgia, myalgia, neuralgia, migraine, toothache, headache, algodysmenorrhea, pain from injuries and burns.
Contraindications
– Hypersensitivity to paracetamol or any other ingredient of the drug;
– Lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
– children under 3 years of age (for this dosage form).
Dosage and administration
- Inside. Dissolve the tablet in a glass of water (200 ml). Do not chew or swallow the tablet. Usually 1? 2 tablets 2? 3 times a day at intervals of at least 4 hours are used.
- The maximum single dose is 2 tablets (1 g), the maximum daily dose is ? 8 tablets (4 g), which corresponds to a single dose of 10-15 mg/kg body weight, for a maximum daily dose ? 75 mg/kg body weight.
- In patients with impaired renal function, the time interval between the doses of the preparation should be at least 8 hours if creatinin clearance is less than 10 ml/min, at least 6 hours if creatinin clearance is 10-50 ml/min.
- In patients with chronic or compensated active liver diseases, especially those with hepatic insufficiency, chronic alcoholism, chronic malnutrition (insufficient glutathione reserve in the liver), dehydration or body weight less than 50 kg a daily dose should not exceed 3 g, i.e. 6 tablets.
- The drug should be used with caution in children and patients with body weight less than 50 kg to exclude the risk of exceeding the recommended dose.
- The duration of use without physician’s consultation should not exceed 5 days when prescribed as a pain reliever and 3 days as an antipyretic.
